Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sustainable Development01:43

Sustainable Development

14.8K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
14.8K
Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

263
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
263
Model Approaches for Pharmacokinetic Data: Compartment Models01:14

Model Approaches for Pharmacokinetic Data: Compartment Models

547
Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
Two primary types of compartment models are recognized: mammillary and catenary. The more...
547
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

247
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
247
One-Compartment Open Model: Urinary Excretion Data and Determination of k01:11

One-Compartment Open Model: Urinary Excretion Data and Determination of k

622
The one-compartment open model leverages urinary excretion data to estimate renal clearance, which gauges the kidney's capacity to expel a drug. This method offers several benefits, including directly measuring drug elimination and assessing the kidney's contribution to overall drug clearance. However, this approach has limitations. It assumes sole renal excretion of the drug, which is not true for all drugs. Accurate urinary excretion and plasma drug concentration measurement can also...
622
Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches01:14

Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

523
Drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
523

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Morpho-cultural, pathogenic, and molecular diversity, and population structure analysis of <i>Bipolaris sorokiniana</i> causing spot blotch disease in wheat.

Frontiers in microbiology·2026
Same author

<i>Escherichia coli</i> in water samples at Bhutan's National Food Testing Laboratory: baseline findings and scoping for antimicrobial resistance surveillance.

Journal of water and health·2026
Same author

Integrating Field Screening and Molecular Diagnostics to Assess Yellow Mosaic Disease Resistance in Selected Mungbean Varieties.

Current microbiology·2026
Same author

Cryoneurolysis for the management of pain secondary to obstetrical brachial plexus injury: a case report.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same author

Gender-just reductions in greenhouse gas emissions in maternity care services through the 'baby- friendly hospital initiative': a scoping review.

International breastfeeding journal·2026
Same author

Genetic dissection and stability analysis of grain protein content and thousand-grain weight in emmer wheat (Triticum turgidum subsp. dicoccum) germplasm.

Scientific reports·2026

Related Experiment Video

Updated: Jan 27, 2026

Infinium Assay for Large-scale SNP Genotyping Applications
13:33

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

39.9K

Development of model web-server for crop variety identification using throughput SNP genotyping data.

Rajender Singh1, M A Iquebal2, C N Mishra1

  • 1ICAR-Indian Institute of Wheat & Barley Research, Karnal, 132001, Haryana, India.

Scientific Reports
|March 28, 2019
PubMed
Summary

Developing DNA-based signatures for crop varieties overcomes limitations of traditional identification. A new web server, VISTa, aids in rapid, accurate wheat variety identification, supporting global germplasm management and intellectual property rights.

More Related Videos

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR
06:18

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

Published on: July 11, 2025

857
A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development
06:49

A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development

Published on: October 29, 2019

7.1K

Related Experiment Videos

Last Updated: Jan 27, 2026

Infinium Assay for Large-scale SNP Genotyping Applications
13:33

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

39.9K
Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR
06:18

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR

Published on: July 11, 2025

857
A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development
06:49

A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development

Published on: October 29, 2019

7.1K

Area of Science:

  • Agricultural Science
  • Genetics
  • Bioinformatics

Background:

  • Morphological identification of crop varieties is time-consuming, costly, and susceptible to phenotypic plasticity.
  • Accurate crop germplasm management is crucial for agricultural production and intellectual property rights (IPR).
  • Existing methods for variety identification lack global accessibility and user-friendly computational tools.

Purpose of the Study:

  • To develop a DNA-based signature for accurate and efficient crop variety identification.
  • To create a server-based tool for global accessibility of phenotypic and genotypic data.
  • To supplement Distinctness, Uniformity, and Stability (DUS) testing with DNA profiling for Plant Breeders Rights (PBR).

Main Methods:

  • Utilized Axiom 35K SNP chip data for over 350 Indian wheat varieties.
  • Developed varietal signatures using standard filtering and linkage disequilibrium approaches in Linux.
  • Built a user-friendly web server (VISTa) using HTML, Java, PHP, and MySQL, including a QR code generator.

Main Results:

  • Successfully developed a DNA-based varietal signature for wheat.
  • Constructed a phylogenetic tree confirming six major trait-based clusters and their pedigrees.
  • Established VISTa, the world's first model web server for crop variety identification.

Conclusions:

  • VISTa provides a user-friendly, globally accessible tool for crop variety identification, aiding DUS testing and dispute resolution.
  • The model approach can be extended to other crops for global germplasm management and enhanced crop productivity.
  • DNA-based signatures and web server tools are essential for modern crop breeding and intellectual property protection.