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Application of the Pipeline Embolization Device for Giant Vertebrobasilar Dissecting Aneurysms in Pediatric Patients

Jiejun Wang1, Yisen Zhang1, Ming Lv1

  • 1Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Frontiers in Neurology
|March 28, 2019
PubMed

Insights

The pipeline embolization device (PED) shows potential feasibility for treating pediatric giant vertebrobasilar dissecting aneurysms (VBDAs). While outcomes were favorable for most young patients, further research is needed to confirm safety and efficacy in this population.

Area of Science:

  • Neurology
  • Interventional Neuroradiology
  • Pediatric Neurosurgery

Background:

  • Pediatric giant vertebrobasilar dissecting aneurysms (VBDAs) are rare and challenging vascular lesions.
  • Treatment options for pediatric VBDAs are limited, necessitating evaluation of novel endovascular techniques.

Purpose of the Study:

  • To assess the feasibility and effectiveness of the pipeline embolization device (PED) for treating pediatric giant VBDAs.
  • To evaluate early outcomes and safety of PED treatment in a pediatric cohort.

Main Methods:

  • Retrospective review of a clinical database of intracranial aneurysms.
  • Identification of pediatric patients (≤18 years) with giant VBDAs treated with PED.
  • Analysis of procedural success, clinical outcomes, and imaging follow-up.

Main Results:

  • Four pediatric patients with giant VBDAs were treated with PED (alone or with coils).
  • One patient experienced a fatal outcome due to brainstem complications.
  • Three patients demonstrated favorable outcomes with reduced mass effect on follow-up MRI.

Conclusions:

  • Pipeline embolization device (PED) may be a feasible treatment option for pediatric giant vertebrobasilar dissecting aneurysms (VBDAs).
  • The safety and long-term efficacy of PED in pediatric patients require further investigation.
  • Long-term follow-up is essential to fully understand the risks and benefits in this unique population.

Keywords:
dissectinggiantpediatricpipelinevertebrobasilar

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