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Related Concept Videos

The Evidence for Evolution02:55

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Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
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Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
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Molecular Evolution of the Tre Recombinase
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Sepsis: The evolution in definition, pathophysiology, and management.

Bishal Gyawali1, Karan Ramakrishna1, Amit S Dhamoon1

  • 1Department of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.

SAGE Open Medicine
|March 28, 2019
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Summary

Sepsis management has evolved, incorporating early goal-directed therapy and recognizing complex pathophysiology beyond infection. Ongoing research explores biomarkers and precision medicine for improved patient outcomes in sepsis care.

Keywords:
Critical care/emergency medicinehematologyinfectious diseases

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Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Pathophysiology

Background:

  • Sepsis definition and management have evolved significantly over 30 years.
  • Pathophysiology understanding now includes coagulation, immunosuppression, and organ dysfunction, not just infection.
  • Early goal-directed therapy has revolutionized sepsis management.

Purpose of the Study:

  • To review progress in sepsis diagnosis and management over two decades.
  • To examine promising future research directions in sepsis.
  • To highlight advances in understanding sepsis pathophysiology.

Main Methods:

  • Review of literature on sepsis definition, pathophysiology, and management.
  • Analysis of the impact of early goal-directed therapy.
  • Examination of current and future research in sepsis biomarkers and targeted therapies.

Main Results:

  • Early goal-directed therapy has improved sepsis outcomes.
  • Current biomarkers lack clinical effectiveness; scoring systems aid risk stratification.
  • Precision medicine and targeted therapies show future potential.

Conclusions:

  • Sepsis management has advanced through improved understanding and early interventions.
  • Further research into biomarkers and precision medicine is crucial for future progress.
  • Targeted therapies addressing inflammatory and coagulatory cascades are promising.