Related Experiment Video
Updated: Jan 27, 2026

Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury
Published on: September 7, 2018
Intrauterine Transfusion Complicated by Umbilical Artery Thrombosis
Roopali V Donepudi1, Kenneth J Moise1
1Department of Obstetrics, Gynecology and Reproductive Medicine, Division of Maternal-Fetal Medicine, UT Health-School of Medicine at Houston, The Fetal Center, Children's Memorial Hermann Hospital, Houston, TX, USA.
Background:
Fetal anemia results from several conditions; however intrauterine transfusion (IUT) remains the treatment for severe cases. The complications of this procedure are rare and yet can result in preterm delivery or fetal death.
Case:
31 y/o G3P2002 with Rh alloimmunization underwent IUT from 19 to 35 weeks. Umbilical artery thrombosis was noted after her 5th IUT. Further transfusions were performed without any complications and she delivered a full term male infant with APGARS of 8 and 9 at 1 and 5 minutes, respectively.
Conclusion:
The complication of umbilical artery thrombosis is unusual and the optimal management is unclear. We report such a case and propose that the presence of Hyrtl's anastomosis near the placental cord insertion may explain the reassuring fetal status throughout the pregnancy.
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