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Parameters of arterial stiffness in patients with Behçet's disease and their relationship with disease duration

Koray Ayar1, Barıs Sensoy2, Mehmet Emin Aslanci3

  • 1Department of Rheumatology, Saglik Bilimleri University, Bursa Yuksek Ihtisas Education and Research Hospital, Bursa, Turkey. ayarkoray@hotmail.com.

Rheumatology International
|March 28, 2019
PubMed

Insights

Arterial stiffness, measured by augmentation index, is higher in Behçet

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Vascular Biology

Background:

  • Arterial stiffness investigations in Behçet's disease (BD) yield conflicting results.
  • Homogenous grouping by disease duration may resolve discrepancies in arterial stiffness findings.
  • Assessing arterial stiffness is crucial for understanding cardiovascular risk in BD.

Purpose of the Study:

  • To compare arterial stiffness using pulse wave velocity (PWV) and augmentation index (AIx).
  • To evaluate differences between healthy controls (HC) and BD patients with short (SDD) and long disease duration (LDD).

Main Methods:

  • Cross-sectional study including 54 BD patients and 34 HC.
  • BD patients categorized into SDD (≤12 months) and LDD groups.
  • Brachial artery measurements of PWV and AIx, alongside cardiovascular risk factors.

Main Results:

  • Augmentation index (AIx) was significantly higher in all BD patient groups (overall, SDD, LDD) compared to HC.
  • Pulse wave velocity (PWV) did not differ between BD patients and HC.
  • PWV was significantly higher in LDD BD patients than in SDD BD patients.
  • A moderate correlation was found between PWV and disease duration.

Conclusions:

  • Augmentation index is elevated in Behçet's disease patients irrespective of disease duration.
  • Increased pulse wave velocity in long-standing Behçet's disease suggests disease progression impacts arterial stiffness.
  • Further research is needed to clarify the role of arterial stiffness in BD pathophysiology and cardiovascular risk.

Keywords:
Arterial stiffnessAugmentation indexBehcet’s diseasePulse wave velocity

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