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OPENMENDEL: a cooperative programming project for statistical genetics.

Hua Zhou1, Janet S Sinsheimer2, Douglas M Bates3

  • 1Department of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, USA. huazhou@ucla.edu.

Human Genetics
|March 28, 2019
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Summary
This summary is machine-generated.

The OPENMENDEL project offers open-source software for genetic epidemiology, addressing big data challenges in genome-wide association studies (GWAS) through scalable and collaborative computational tools.

Keywords:
Collaborative programmingComputational statisticsGWASOpen sourceStatistical genomics

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Area of Science:

  • Genetics
  • Biostatistics
  • Computational Biology

Background:

  • Genome-wide association studies (GWAS) generate large, complex datasets.
  • Existing statistical methods require enhanced computational efficiency and data handling.
  • The increasing volume and variety of genetic data necessitate advanced software solutions.

Purpose of the Study:

  • To introduce the OPENMENDEL project as a collaborative open-source software initiative.
  • To address the computational and data manipulation challenges in genetic epidemiology.
  • To facilitate reproducible and scalable analyses for big genetic data.

Main Methods:

  • Development of open-source software (OPENMENDEL) for genetic epidemiology.
  • Focus on interactive, reproducible analyses with informative intermediate results.
  • Implementation of features for big data analytics, parallel/distributed computing, and cloud computing.

Main Results:

  • OPENMENDEL aims to enable scalable big data analytics for genetic epidemiology.
  • The project supports integration of diverse genetic data types.
  • It fosters collaboration among clinicians, geneticists, statisticians, and computer scientists.

Conclusions:

  • OPENMENDEL provides a framework for modern genetic epidemiology research.
  • The project addresses the need for efficient, collaborative, and adaptable software tools.
  • Recommendations are made to the genetic epidemiology community regarding the adoption of such tools.