Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

16.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.2K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

7.6K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
7.6K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

16.3K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
16.3K
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

956
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
956
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

490
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
490
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.0K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary <i>Bacillus subtilis</i> Improves Growth Performance, Digestive Enzyme Activity, Antioxidant and Inflammatory Responses, and Gut Microbiota in Juvenile GIFT (<i>Oreochromis niloticus</i>).

Animals : an open access journal from MDPI·2026
Same author

Maize-recruited Bacillus velezensis inhibit Fusarium oxysporum by directly secreting antimicrobial metabolites.

Microbiological research·2026
Same author

Micro-CT dynamic changes and molecular mechanisms in a pulmonary nodule mouse model induced by Benzo[a]pyrene and lipopolysaccharide.

Journal of thoracic disease·2026
Same author

Production of Tellurene Nanoribbons.

Small methods·2026
Same author

Automated vision-language framework for kinematic profiling and performance diagnostics in competitive swimming.

BMC sports science, medicine & rehabilitation·2026
Same author

SERINC3 promotes osteogenic differentiation of BMSCs via IL-32/AMPK-mediated autophagy and mitochondrial energy metabolism.

Stem cell research & therapy·2026

Related Experiment Video

Updated: Jan 27, 2026

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1&#946; using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

27.0K

Pro-inflammatory Cytokines and Osteocytes.

Miao Zhou1, Shuyi Li1, Janak L Pathak2

  • 1Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Affiliated Stomatology Hospital of Guangzhou Medical University, Huangsha Avenue 39, Guangzhou, 510140, China.

Current Osteoporosis Reports
|March 28, 2019
PubMed
Summary

Pro-inflammatory cytokines in inflammatory conditions harm osteocyte survival and function. This can worsen inflammation, leading to bone loss and complications in other organs.

Keywords:
Bone homeostasis, non-bone clinical complicationsEndocrine functionInflammatory diseasesOsteocytesPro-inflammatory cytokines

More Related Videos

Analysis and Imaging of Osteocytes
10:19

Analysis and Imaging of Osteocytes

Published on: November 29, 2024

1.3K
Obtaining Primary Osteocytes Through Murine Calvarial Fractionation of GFP-Expressing Osteocytes
07:22

Obtaining Primary Osteocytes Through Murine Calvarial Fractionation of GFP-Expressing Osteocytes

Published on: June 2, 2020

2.6K

Related Experiment Videos

Last Updated: Jan 27, 2026

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1&#946; using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

27.0K
Analysis and Imaging of Osteocytes
10:19

Analysis and Imaging of Osteocytes

Published on: November 29, 2024

1.3K
Obtaining Primary Osteocytes Through Murine Calvarial Fractionation of GFP-Expressing Osteocytes
07:22

Obtaining Primary Osteocytes Through Murine Calvarial Fractionation of GFP-Expressing Osteocytes

Published on: June 2, 2020

2.6K

Area of Science:

  • Bone biology
  • Inflammation research
  • Cellular signaling

Background:

  • Osteocytes are crucial bone cells (>95% of bone cellularity) producing signaling molecules.
  • Pro-inflammatory cytokines are implicated in bone loss and organ dysfunction during inflammation.

Purpose of the Study:

  • To review how elevated pro-inflammatory cytokines impact osteocyte survival and function.
  • To explore the role of osteocytes in amplifying inflammation and causing bone/organ complications.

Main Methods:

  • Literature review of studies on inflammation, cytokines, and osteocytes.
  • Analysis of molecular mechanisms linking inflammation to osteocyte responses.

Main Results:

  • Pro-inflammatory cytokines alter osteocyte mechanosensitivity and promote apoptosis.
  • Osteocytes release signaling molecules affecting bone and distant organs.
  • Inflammatory diseases disrupt osteocyte function and upregulate key molecules (sclerostin, RANKL, TNFα, FGF23, DKK1).

Conclusions:

  • Osteocyte dysfunction driven by inflammation contributes to bone loss.
  • Altered osteocyte signaling exacerbates systemic inflammation and non-bone complications.