Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Wave Parameters01:10

Wave Parameters

9.1K
The simplest mechanical waves are associated with simple harmonic motion and repeat themselves for several cycles. These simple harmonic waves can be modeled using a combination of sine and cosine functions. Consider a simplified surface water wave that moves across the water's surface. Unlike complex ocean waves, in surface water waves, water moves vertically, oscillating up and down, whereas the disturbance of the wave moves horizontally through the medium. If a seagull is floating on the...
9.1K
Distributions to Estimate Population Parameter01:26

Distributions to Estimate Population Parameter

5.1K
The accurate values of population parameters such as population proportion, population mean, and population standard deviation (or variance) are usually unknown. These are fixed values that can only be estimated from the data collected from the samples. The estimates of each of these parameters are sample proportion, the sample mean, and sample standard deviation (or variance). To obtain the values of these sample statistics, data are required that have particular distribution and central...
5.1K
Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters00:54

Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters

446
The noncompartmental approach is a widely used method in pharmacokinetics to assess drugs' behaviors in the body. It considers several factors, including clearance, bioavailability, and total volume of distribution.
One key aspect of the noncompartmental approach is determining a drug's total clearance. This can be done by dividing the drug dose by the area under the concentration-time curve from zero to infinity. The area under the concentration-time curve represents the drug's...
446
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

161
It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
161
Factors Influencing Drug Absorption: Anatomical Parameters01:23

Factors Influencing Drug Absorption: Anatomical Parameters

599
Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
599
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

830
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
830

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Clinical Respiratory Score: Diagnostic Performance for Acute Chest Syndrome in Sickle Cell Disease.

Pediatric pulmonology·2026
Same author

Exploratory research in immune TTP and other ultra-rare diseases-Balancing statistical idealism with pragmatic discovery.

British journal of haematology·2026
Same author

Clinical predictors of mortality in immune thrombotic thrombocytopenic purpura: A National Inpatient Sample analysis.

British journal of haematology·2026
Same author

Immune Checkpoint Inhibitor Outcomes Across Child-Pugh A, B, and C Hepatocellular Carcinoma: A Real-World Integrated Health-System Cohort.

Cancer treatment and research communications·2026
Same author

Reply: Validation of MELD 3.0 in 2 centers from different continents.

Hepatology communications·2026
Same author

Kidney safety net utilization after liver transplant for acute alcohol-associated hepatitis.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026

Related Experiment Video

Updated: Jan 27, 2026

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
06:28

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

7.2K

Thromboelastography Parameters Are Associated with Cirrhosis Severity.

Ruhail Kohli1, Alexandra Shingina2,3, Stephen New4

  • 1Division of Gastroenterology and Hepatology, Johns Hopkins Bayview Medical Center, The Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, MD, 21224, USA.

Digestive Diseases and Sciences
|March 28, 2019
PubMed
Summary

Thromboelastography (TEG) reveals hypocoagulable parameters in advanced cirrhosis and higher MELD-Na scores. These findings suggest TEG can objectively assess liver disease severity.

Keywords:
Blood coagulation disordersEnd-stage liver diseaseMELD-NaPortal hypertensionTEG

More Related Videos

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

797
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.4K

Related Experiment Videos

Last Updated: Jan 27, 2026

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
06:28

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

7.2K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

797
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.4K

Area of Science:

  • Hepatology
  • Coagulation Science
  • Transplant Medicine

Background:

  • Cirrhosis causes complex coagulation derangements.
  • Thromboelastography (TEG) measures these hemostatic abnormalities.

Purpose of the Study:

  • To investigate the association between TEG parameters and validated measures of cirrhosis severity.
  • To explore the relationship between TEG and MELD-Na and clinical stage of cirrhosis.

Main Methods:

  • Adults with cirrhosis undergoing liver transplant (LT) had TEG performed prior to LT.
  • TEG parameters (R, K, α, MA) were analyzed against MELD-Na and clinical cirrhosis stage.
  • Multivariable regression models assessed associations, adjusting for covariates.

Main Results:

  • Advancing cirrhosis stage correlated with hypocoagulable TEG (longer K, lower MA).
  • Increasing MELD-Na quartiles showed longer K, decreased MA and α-angle.
  • Recent variceal bleeding was linked to prolonged R and K, smaller α, and lower MA.

Conclusions:

  • Hypocoagulable TEG measurements are linked to advanced cirrhosis and higher MELD-Na.
  • TEG serves as an objective marker for assessing liver disease severity in cirrhosis.
  • TEG provides valuable insights into complex hemostatic function in cirrhotic patients.