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Hyperglycemia effect on red blood cells indices
B N Alamri1, A Bahabri, A A Aldereihim
1Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. krubeaan@dsrcenter.org.
European Review for Medical and Pharmacological Sciences
|March 28, 2019
Summary
Hyperglycemia significantly impacts red blood cells (RBCs) count and function, increasing RBC count and size. Good glycemic control can normalize these changes in diabetic patients.
Area of Science:
- Endocrinology
- Hematology
- Diabetology
Background:
- Hyperglycemia affects all tissues, including bone marrow.
- Protein glycation and physiological changes in red blood cells (RBCs) are linked to hyperglycemia.
- Understanding these RBC changes is crucial for managing diabetes complications.
Purpose of the Study:
- To assess the impact of hyperglycemia on various RBC indices.
- To evaluate RBC changes in normal physiology versus chronic diabetes pathology.
- To investigate the relationship between hyperglycemia and RBC parameters in Saudi type 2 diabetic patients.
Main Methods:
- Cross-sectional, hospital-based study.
- Involved 1000 Saudi type 2 diabetic patients without hematological diseases.
- Comprehensive clinical, biochemical, and hematological assessments were performed.
Main Results:
- Hyperglycemia was associated with increased RBC count, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC).
- Red blood cell distribution width (RDW) showed a negative correlation with glycemic control.
- Micro- and macroangiopathies in hyperglycemic patients shortened RBC lifespan.
Conclusions:
- Hyperglycemia exerts a significant influence on RBC count and physiological function.
- Effective glycemic control can normalize hyperglycemia-induced alterations in RBCs.
- RBC indices serve as potential indicators of glycemic control and diabetes complications.
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