Related Experiment Video

Updated: Jan 27, 2026

Author Spotlight: Advancing Protein Engineering – Harnessing Evolution Through PRANCE and Lab Automation
05:08

Author Spotlight: Advancing Protein Engineering – Harnessing Evolution Through PRANCE and Lab Automation

Published on: January 12, 2024

2.2K

Future of paediatric sedation: towards a unified goal of improving practice

Keira P Mason1, Neena Seth2

  • 1Harvard Medical School, Boston Children's Hospital, Department of Anesthesiology, Critical Care and Pain Medicine, Boston, MA, USA.

British Journal of Anaesthesia
|March 28, 2019
PubMed

Insights

The future of pediatric sedation involves evaluating adverse events and exploring new uses for existing sedatives. Large-scale studies are crucial for safer sedation practices and improved patient experiences.

Area of Science:

  • Pediatric Anesthesiology
  • Pharmacology
  • Patient Safety

Background:

  • Paediatric sedation is essential for medical procedures in children.
  • Current practices require ongoing evaluation for safety and efficacy.
  • Limited development of novel paediatric sedatives necessitates innovative approaches.

Purpose of the Study:

  • To provide a perspective on the future of paediatric sedation.
  • To highlight areas for improvement in sedation practices.
  • To emphasize the need for evidence-based advancements.

Main Methods:

  • Review of current literature and practices in paediatric sedation.
  • Analysis of potential strategies for enhancing sedation delivery.
  • Discussion of the role of monitoring and non-pharmacological interventions.

Main Results:

  • Future sedation will focus on risk factor evaluation and predictive modeling for adverse events.
  • Exploration of novel administration routes, indications, and techniques for existing sedatives is key.
  • Integration of non-pharmacological anxiolysis and advanced monitoring can optimize sedation.

Conclusions:

  • Understanding sedative mechanisms is vital for targeted sedation.
  • Large-scale, globally contributed studies are necessary to drive practice changes.
  • The ultimate goal is to enhance patient safety and experience in paediatric sedation.

Keywords:
ADV6209anaesthesiaanxiolysisketaminemidazolammonitoringpatient safetysedation

More Related Videos

A Unified Methodological Framework for Vestibular Schwannoma Research08:43

A Unified Methodological Framework for Vestibular Schwannoma Research

Published on: June 20, 2017

7.8K
An Inexpensive, Scalable Behavioral Assay for Measuring Ethanol Sedation Sensitivity and Rapid Tolerance in Drosophila07:28

An Inexpensive, Scalable Behavioral Assay for Measuring Ethanol Sedation Sensitivity and Rapid Tolerance in Drosophila

Published on: April 15, 2015

10.6K

Related Concept Videos

Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
486
Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
1.5K
Sedatives and Hypnotics Drugs: Barbiturates01:20

Sedatives and Hypnotics Drugs: Barbiturates

Sedatives and hypnotics encompass a drug class that acts on the central nervous system (CNS) to alleviate anxiety, promote relaxation and induce sleep.These drugs function by amplifying the actions of the neurotransmitter γ-aminobutyric acid (GABA), resulting in reduced neuronal activity. Barbiturates, a subset of sedatives and hypnotics first synthesized in the late 1800s, are categorized into ultra-short, short, intermediate, and long-acting groups based on their duration of effect. A...
1.0K
Sedatives and Hypnotics Drugs: Benzodiazepines01:19

Sedatives and Hypnotics Drugs: Benzodiazepines

Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
844
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
553
Characteristics of Practical Op Amps01:16

Characteristics of Practical Op Amps

A difference amplifier, a crucial component in numerous electronic devices, ideally amplifies only the difference-mode signal, which is the difference between two input signals. However, in practical circuits, the output voltage depends on both the differential gain and the common-mode gain.
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...
844