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The Expression of and Preoperative Correlation between Heat-Shock Protein 70, EuroSCORE, and Lactate in Patients

Marcos Antonio Cantero1, Rui Manuel Siqueira Almeida2, Priscila Neder Morato3

  • 1Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, Brazil.

Brazilian Journal of Cardiovascular Surgery
|March 28, 2019
PubMed

Insights

Heat-shock protein 70 (HSP 70) may predict uncomplicated recovery after coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB). Higher HSP 70 levels were observed in patients with uncomplicated postoperative evolution.

Area of Science:

  • Cardiovascular Surgery
  • Biomarkers
  • Inflammatory Response

Background:

  • Coronary artery bypass grafting (CABG) using cardiopulmonary bypass (CPB) improves outcomes for coronary artery disease but can trigger systemic inflammation and adverse effects.
  • Predicting postoperative complications is crucial for patient management and risk stratification.

Purpose of the Study:

  • To assess heat-shock protein 70 (HSP 70) as a predictor of morbidity and mortality in patients undergoing CABG with CPB.
  • To correlate HSP 70 expression with lactate levels (tissue hypoperfusion marker) and EuroSCORE risk in patients with preserved ventricular function.

Main Methods:

  • Prospective, observational study of 46 patients undergoing myocardial revascularization with extracorporeal circulation.
  • Patients were categorized into complicated and uncomplicated postoperative evolution groups.
  • EuroSCORE, lactate, and HSP 70 levels were measured and analyzed for correlations.

Main Results:

  • Patients with complicated evolution had significantly higher EuroSCORE values.
  • HSP 70 protein levels were significantly increased in the uncomplicated postoperative evolution group.
  • HSP 70 may serve as an independent predictor of uncomplicated recovery in this patient cohort.

Conclusions:

  • Heat-shock protein 70 (HSP 70) shows potential as a valuable biomarker for predicting uncomplicated outcomes in cardiac surgery.
  • HSP 70 may act as a discriminator and protective marker against complications following CABG with CPB.
Abstract

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