Related Experiment Video

Updated: Jan 27, 2026

Recovery of Adult Zebrafish Hearts for High-throughput Applications
06:51

Recovery of Adult Zebrafish Hearts for High-throughput Applications

Published on: December 12, 2014

12.9K

External applicability of the COMPASS trial: the Western Denmark Heart Registry

Morten Würtz1,2, Kevin Kris Warnakula Olesen1,3, Troels Thim1

  • 1Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK Aarhus, Denmark.

European Heart Journal. Cardiovascular Pharmacotherapy
|March 28, 2019
PubMed

Insights

In a study of patients undergoing coronary angiography, only 15% met criteria for combined aspirin and rivaroxaban treatment. These eligible patients experienced significantly higher cardiovascular event rates, indicating an unmet need for better prevention strategies.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Trials
  • Epidemiology

Background:

  • The COMPASS trial demonstrated benefits of combined aspirin and rivaroxaban for ischemic events in stable coronary artery disease (CAD) or peripheral artery disease (PAD).
  • Determining the proportion of patients eligible for this treatment in real-world settings is crucial for understanding its potential impact.

Purpose of the Study:

  • To estimate the prevalence of COMPASS-eligible patients among unselected individuals undergoing coronary angiography (CAG).
  • To compare cardiovascular event rates between COMPASS-eligible and non-eligible patients with CAD/PAD.

Main Methods:

  • A cohort of 80,071 patients undergoing CAG in Western Denmark (2004-2011) was analyzed.
  • COMPASS eligibility criteria were applied to identify patients with CAD/PAD who met inclusion criteria.
  • Primary endpoint (cardiovascular death, ischemic stroke, hemorrhagic stroke, myocardial infarction) rates were compared using adjusted incidence rate ratios (aIRRs).

Main Results:

  • Of 52,132 patients with CAD/PAD, 11,930 (approximately 23%) were COMPASS eligible.
  • COMPASS eligible patients had a 1.7-fold higher rate of the primary endpoint compared to non-eligible patients.
  • Higher risks were observed for cardiovascular death (aIRR 2.5), ischemic stroke (aIRR 1.4), and myocardial infarction (aIRR 1.9) in eligible patients.

Conclusions:

  • Only 15% of the studied 'all-comers' CAG cohort were eligible for the COMPASS treatment regimen.
  • COMPASS-eligible patients exhibited substantially higher rates of cardiovascular events, up to 2.5 times greater than non-eligible counterparts.
  • These findings underscore an unmet need for enhanced preventive strategies in high-risk cardiovascular patients.
Abstract

Keywords:
AspirinCOMPASS trialCoronary artery diseasePeripheral artery diseaseRivaroxaban

More Related Videos

In Silico Clinical Trials for Cardiovascular Disease09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.2K
The Fastest Western in Town: A Contemporary Twist on the Classic Western Blot Analysis11:43

The Fastest Western in Town: A Contemporary Twist on the Classic Western Blot Analysis

Published on: February 5, 2014

28.0K

Related Concept Videos

Compass01:23

Compass

The compass is a fundamental instrument that operates by aligning its magnetic needle with Earth's magnetic field. This alignment facilitates navigation and orientation, offering a means to determine direction relative to magnetic north. However, the magnetic needle points to magnetic north, which differs slightly from true geographic north due to magnetic declination, which is the angular deviation between these two points. Declination varies based on geographic location and shifts over time...
6.7K
Western Blotting01:15

Western Blotting

Western blotting is an analytical technique for protein identification. It has various applications in immunology and medicine, including detecting diseases like bovine spongiform encephalopathy, mad cow disease, and human and feline immunodeficiency virus from biological samples.
The technique begins with separating proteins from the sample using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), followed by protein transfer, immunoblotting, and finally, protein detection.
20.4K
Design Example: Marking Boundaries of a Site Using a Compass01:12

Design Example: Marking Boundaries of a Site Using a Compass

Marking site boundaries using a compass is a precise surveying technique that ensures the accuracy of boundary delineation. The process begins by using provided site details, including the bearings and lengths of each boundary line. The initial step involves calculating latitudes and departures for all sides of the site. This computation verifies that the traverse is free of errors, ensuring a closed and accurate boundary.The process starts at a known point, such as Point A, which is often...
290
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.2K
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.7K
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
404