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Integration of congenital cytomegalovirus screening within a newborn hearing screening programme

Rachael Beswick1, Michael David2, Hideki Higashi3

  • 1Child and Youth Community Health, Children's Health Queensland Hospital and Health Service, Brisbane, Queensland, Australia.

Journal of Paediatrics and Child Health
|March 28, 2019
PubMed

Insights

Targeted salivary cytomegalovirus (CMV) screening for newborns referred from hearing tests is feasible and cost-effective. This approach can identify congenital CMV (cCMV) early to improve hearing outcomes.

Area of Science:

  • Neonatal screening
  • Infectious disease diagnostics
  • Public health interventions

Background:

  • Congenital cytomegalovirus (cCMV) is a leading cause of non-genetic sensorineural hearing loss in infants.
  • Early identification and intervention for cCMV can mitigate hearing impairment.
  • Current screening methods for cCMV are limited in widespread application.

Purpose of the Study:

  • To evaluate the feasibility and cost-effectiveness of implementing targeted salivary cytomegalovirus (CMV) polymerase chain reaction (PCR) testing within a newborn hearing screening program.
  • To assess the practical and financial viability of integrating cCMV screening into existing audiology referral pathways.

Main Methods:

  • A prospective study was conducted across three tertiary maternity hospitals in Queensland, Australia.
  • Infants referred from newborn hearing screening were offered salivary swabs for CMV PCR testing.
  • Positive CMV PCR results triggered medical assessment and potential treatment with oral valganciclovir.

Main Results:

  • Parental consent for salivary cCMV screening was high at 83.0%.
  • The prevalence of cCMV in infants with confirmed hearing loss was 3.64%.
  • Implementation costs for cCMV screening were found to be negligible compared to non-screening management.

Conclusions:

  • Integrating salivary cCMV testing into universal newborn hearing screening is a realistic and achievable strategy.
  • The program demonstrated practical feasibility and financial viability in the Australian context.
  • This targeted screening approach holds promise for improving hearing outcomes in infants with cCMV.
Abstract

Keywords:
congenital cytomegaloviruscost-benefithearing losstargeted screening

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