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Deregulation of SATB2 in carcinogenesis with emphasis on miRNA-mediated control

Qiao Yi Chen1, Thomas Des Marais1, Max Costa1

  • 1Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.

Carcinogenesis
|March 28, 2019
PubMed

Insights

Special AT-rich DNA binding protein (SATB2) is crucial for development and its dysregulation links to cancer. MicroRNAs (miRNAs) regulate SATB2, offering potential therapeutic strategies for various cancers.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Special AT-rich DNA binding protein (SATB2) is a key transcription factor involved in development, gene regulation, and chromatin remodeling.
  • Dysregulation of SATB2 is strongly associated with multiple cancers, including lung, colon, prostate, breast, gastric, and liver cancers.
  • MicroRNAs (miRNAs), a class of small non-coding RNAs, are emerging as critical post-transcriptional regulators of gene expression and cellular development.

Purpose of the Study:

  • To review the molecular functions of SATB2 and its regulation by miRNAs in the context of cancer development.
  • To explore potential therapeutic strategies for cancer targeting SATB2 and miRNA interactions.
  • To focus on the application of systemic miRNA delivery for cancer treatment.

Main Methods:

  • Literature review of studies on SATB2 function and miRNA regulation in cancer.
  • Analysis of evidence linking specific miRNAs (e.g., miR-31, miR-34, miR-182, miR-211, miR-599) to SATB2 modulation in various cancer types.
  • Examination of current and potential cancer therapy strategies involving SATB2 and miRNA pathways.

Main Results:

  • SATB2 plays a significant role in cellular processes relevant to cancer.
  • Several miRNAs have been identified as regulators of SATB2 in lung, liver, colon, and breast cancers.
  • The interplay between SATB2 and miRNAs presents novel avenues for cancer diagnostics and therapeutics.

Conclusions:

  • SATB2 and miRNA dysregulation are implicated in the pathogenesis of various cancers.
  • Targeting the SATB2-miRNA axis offers promising therapeutic potential.
  • Systemic miRNA delivery represents a viable strategy for future cancer treatments.

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