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The Kinome of Human Alveolar Type II and Basal Cells, and Its Reprogramming in Lung Cancer

Sonia M Leach1,2, Jay Finigan3, Vihas T Vasu4

  • 1Department of Biomedical Research.

American Journal of Respiratory Cell and Molecular Biology
|March 28, 2019
PubMed

Insights

Lung cancer progenitor cells have distinct kinase profiles. Their kinomes change upon transformation into lung adenocarcinomas and squamous cell carcinomas, revealing lineage-specific reprogramming.

Area of Science:

  • Molecular biology
  • Cancer research
  • Cell biology

Background:

  • Mutant tyrosine kinases are key drivers in lung adenocarcinoma development and therapy.
  • The kinome of lung cancer progenitor cells and its reprogramming during transformation remain poorly understood.

Purpose of the Study:

  • To investigate the kinome differences between lung cancer progenitor cells (alveolar type II cells and basal cells) and their transformed counterparts.
  • To determine if kinome reprogramming is lineage-specific during lung cancer development.

Main Methods:

  • RNA sequencing was performed on freshly isolated human alveolar type II cells, basal cells, and lung cancer cell lines.
  • Comparative analysis of kinome expression in non-transformed progenitor cells and transformed carcinoma cells.

Main Results:

  • Distinct kinome profiles were identified for alveolar type II cells and basal cells.
  • Significant changes in kinome expression were observed upon transformation of these progenitor cells into their respective carcinomas.

Conclusions:

  • Lung cancer progenitor cells possess unique kinomes that are altered during malignant transformation.
  • These findings highlight lineage-specific kinome reprogramming in lung cancer, offering potential therapeutic targets.
Keywords:
alveolar type II cellsbasal cellskinomelung adenocarcinomalung squamous cell carcinoma

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