Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection00:59

Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection

416
In pharmacokinetics, the elimination rate of a drug following a capacity-limited model is primarily controlled by two parameters: Vmax and KM. These parameters are crucial in how the drug behaves inside the body after administration.
Following the administration of a single intravenous (IV) bolus injection, we can determine the concentration of the drug in the plasma at any given time. This calculation is achieved using a specific equation that integrates the values of Vmax and KM.
We can also...
416
Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

739
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
739
Two-Compartment Open Model: IV Bolus Administration01:18

Two-Compartment Open Model: IV Bolus Administration

1.1K
The two-compartment model for intravenous (IV) bolus administration illustrates drug distribution in the body, subdividing it into central and peripheral compartments. This model operates on the concept of two-compartment kinetics. The drug's plasma concentration shows a bi-exponential decline following IV bolus administration, signaling the presence of two disposition processes: distribution and elimination.
The disparity between drug input and the sum of drug transfer rates between...
1.1K
Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

12.9K
Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
12.9K
Voltammetric Techniques: Linear-Scan (E vs Time)01:12

Voltammetric Techniques: Linear-Scan (E vs Time)

1.1K
Polarography is a classical voltammetric technique used to analyze electrochemical reactions. This method applies a linear potential sweep to a dropping mercury electrode (DME), and the resulting current is measured. A dropping mercury electrode is commonly used as the working electrode in polarography. It consists of a capillary tube filled with mercury, where the tiny droplet forms at the tip. This droplet continuously drops from the capillary, creating a new electrode surface for each...
1.1K
One-Compartment Open Model for IV Bolus Administration: General Considerations01:19

One-Compartment Open Model for IV Bolus Administration: General Considerations

715
The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...
715

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pathology-validated prevalence and clinical characteristics of coronary medial arterial calcification.

European heart journal open·2026
Same author

Stage- and Region-Dependent Proteomic Alterations in a Mouse Model of Creatine Transporter Deficiency.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Mechanochemical Intramolecular C(sp<sup>3</sup>)-H/C(sp<sup>2</sup>)-H Coupling for Synthesis of Acridine and Anthracene Skeletons.

Organic letters·2026
Same author

Small intestine-permeable cyclic peptide-mediated enhancement of Fc-fusion protein absorption in mice.

Journal of pharmaceutical sciences·2026
Same author

Dendriform pulmonary ossification in fibrosing interstitial lung disease with primary biliary cholangitis.

BMJ case reports·2026
Same author

Normal-resolution vs. super-resolution deep learning reconstruction for diagnosis of functionally significant coronary stenosis using cardiac CT.

Journal of cardiovascular computed tomography·2026

Related Experiment Video

Updated: Jan 27, 2026

Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging
09:32

Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging

Published on: December 9, 2021

3.4K

Double ROI Timing Bolus Technique to Perform Aortic CT Angiography With a 9-Second Contrast Injection Duration.

Nobuo Tomizawa1,2,3, Shingo Ito1,2,3, Tastuya Nakao1,2,3

  • 1Department of Radiology, New Tokyo Hospital, 1271 Wanagaya, Matsudo, Chiba, Japan, 270-2232.

AJR. American Journal of Roentgenology
|March 28, 2019
PubMed
Summary

This study shows a new double region of interest (ROI) timing bolus technique for aortic CT angiography (CTA). It significantly reduces contrast medium and radiation dose while improving image quality.

Keywords:
CT angiographyaortacontrast mediumtiming bolus technique

More Related Videos

Improved Registration of 3D CT Angiography with X-ray Fluoroscopy for Image Fusion During Transcatheter Aortic Valve Implantation
06:59

Improved Registration of 3D CT Angiography with X-ray Fluoroscopy for Image Fusion During Transcatheter Aortic Valve Implantation

Published on: June 3, 2018

11.0K
Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

899

Related Experiment Videos

Last Updated: Jan 27, 2026

Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging
09:32

Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging

Published on: December 9, 2021

3.4K
Improved Registration of 3D CT Angiography with X-ray Fluoroscopy for Image Fusion During Transcatheter Aortic Valve Implantation
06:59

Improved Registration of 3D CT Angiography with X-ray Fluoroscopy for Image Fusion During Transcatheter Aortic Valve Implantation

Published on: June 3, 2018

11.0K
Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

899

Area of Science:

  • Radiology
  • Medical Imaging
  • Cardiovascular Imaging

Background:

  • Aortic CT angiography (CTA) is crucial for diagnosing aortic diseases.
  • Conventional CTA methods often require substantial contrast medium volumes and radiation exposure.
  • Optimizing contrast delivery and scan parameters is essential for improving diagnostic accuracy and patient safety.

Purpose of the Study:

  • To evaluate the feasibility of a double region of interest (ROI) timing bolus technique for aortic CTA.
  • To assess the efficacy of this technique in reducing contrast medium volume and radiation dose.
  • To compare the enhancement characteristics of the double ROI technique with the conventional method.

Main Methods:

  • A prospective study involving 106 patients undergoing aortic CTA.
  • Implementation of a double ROI timing bolus technique using 40 mL of contrast medium over 9 seconds.
  • Calculation of scanning speed based on time-attenuation curves of the aorta.
  • Comparison with a conventional CTA method using 1.7 mL/kg body weight for 25 seconds.

Main Results:

  • The double ROI technique significantly reduced contrast volume (40 mL vs. 88.0 ± 9.4 mL).
  • Aortoiliac enhancement was significantly improved (403.3 ± 76.0 HU vs. 359.7 ± 61.5 HU).
  • Superior vena cava enhancement was significantly decreased (118.9 ± 46.2 HU vs. 239.2 ± 130.5 HU).
  • Effective radiation dose was significantly lower with the double ROI technique (8.3 ± 1.7 mSv vs. 12.4 ± 3.2 mSv).

Conclusions:

  • The double ROI timing bolus technique is a feasible and effective method for aortic CTA.
  • This technique significantly reduces contrast medium and radiation dose.
  • Improved aortic enhancement and reduced scatter radiation are key benefits.