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Updated: Jan 27, 2026

The Benthic Exchange of O2, N2 and Dissolved Nutrients Using Small Core Incubations
Published on: August 3, 2016
Relative Configurational Assignment of 4-Hydroxyprorocentrolide and Prorocentrolide C Isolated from a Benthic
Sangbum Lee1, A Reum Yang1, Yeong Du Yoo1
1Department of Marine Biotechnology , Kunsan National University , 558 Daehak-ro , Gunsan 54150 , South Korea.
Abstract:
Herein, we clarify the structure and relative configurations of two prorocentrolide analogues (1 and 2) isolated from the benthic marine dinoflagellate Prorocentrum lima. The results of NMR spectroscopy show that 1 is prorocentrolide substituted by a hydroxy group at C-4, while the newly isolated compound 2 can be thought of as 1 lacking one ether ring and having one extra double bond. The relative configurations of all stereogenic centers and the configurations of the double bonds in 1 and 2 were determined utilizing ROESY correlations and J-based configuration analysis. Furthermore, 2 was shown to exhibit cytotoxicity against HCT-116 and Neuro-2a cells (IC50 2.2 and 5.2 μM, respectively.
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