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Updated: Jan 27, 2026
07:52
Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
20.5K
[Prognosis analysis of primary breast diffuse large B cell lymphoma]
1Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology]
|March 28, 2019
Summary
Primary breast diffuse large B-cell lymphoma (PB-DLBCL) has a good prognosis. Ann Arbor stage impacts overall survival, while B symptoms affect progression-free survival in PB-DLBCL patients.
Area of Science:
- Oncology
- Hematology
- Clinical Medicine
Background:
- Primary breast diffuse large B-cell lymphoma (PB-DLBCL) is a rare non-Hodgkin lymphoma.
- Understanding its clinical characteristics, treatment, and prognosis is crucial for patient management.
Purpose of the Study:
- To investigate the clinical characteristics, therapy, and prognosis of PB-DLBCL.
- To identify independent prognostic factors for overall survival (OS) and progression-free survival (PFS).
Main Methods:
- Retrospective analysis of 68 PB-DLBCL patients treated between 2004 and 2017.
- Kaplan-Meier method for univariate survival analysis.
- Cox regression analysis for multivariate survival analysis.
Main Results:
- The 5-year OS rate was 73.0% and the 5-year PFS rate was 51.0%.
- Ann Arbor clinical stage was an independent prognostic factor for OS (P=0.029).
- B symptoms were an independent prognostic factor for PFS (P=0.028).
Conclusions:
- PB-DLBCL generally has a favorable prognosis.
- Ann Arbor clinical stage and B symptoms are significant independent prognostic factors for OS and PFS, respectively.
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