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The moment of a force, also known as torque, measures the ability of the force to create rotational motion in a body about an axis. It is a vector quantity, meaning it has both magnitude and direction. This concept is used extensively in engineering, physics, and mechanics.
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Levan-Capped Silver Nanoparticles for Bactericidal Formulations: Release and Activity Modelling.

Álvaro González-Garcinuño1, Rubén Masa2, María Hernández3

  • 1Department of Chemical Engineering, University of Salamanca, 37008 Salamanca, Spain. alvaro_gonzalez@usal.es.

International Journal of Molecular Sciences
|March 29, 2019
PubMed
Summary

Environmentally friendly silver nanoparticles show potent bactericidal effects against E. coli and B. subtilis. A novel model predicts silver release and bacterial inhibition for future gel applications.

Keywords:
levanmodellingnanoparticlessilver

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Microbiology

Background:

  • Development of novel antimicrobial agents is crucial for combating bacterial infections.
  • Silver nanoparticles (AgNPs) are known for their broad-spectrum antimicrobial properties.
  • Levan, a natural polysaccharide, offers a biocompatible capping agent for nanoparticles.

Purpose of the Study:

  • To synthesize and characterize levan-capped silver nanoparticles (Levan-AgNPs) with bactericidal activity.
  • To develop a predictive model for silver release and antibacterial efficacy from a gel-based delivery system.
  • To assess the potential of Levan-AgNPs in preventing bacterial growth.

Main Methods:

  • Green synthesis of levan-capped silver nanoparticles (30 nm, 30% loading).
  • Evaluation of bactericidal activity against Escherichia coli (E. coli) and Bacillus subtilis (B. subtilis).
  • Mathematical modeling of dose-response, silver release kinetics, and bacterial inhibition.

Main Results:

  • Levan-AgNPs exhibited significant bactericidal effects against both E. coli (lethal dose: 12.4 ppm) and B. subtilis (lethal dose: 6.8 ppm).
  • A predictive model was successfully developed to accurately forecast silver release and lethal doses from a silver-infused gel.
  • The model demonstrated potential for predicting antibacterial activity against various bacterial species.

Conclusions:

  • Levan-capped silver nanoparticles represent an effective and eco-friendly antimicrobial agent.
  • The developed predictive model offers a valuable tool for designing future silver-based antimicrobial gel formulations.
  • This research paves the way for advanced applications of nanotechnology in infection control.