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Resveratrol Anti-Obesity Effects: Rapid Inhibition of Adipocyte Glucose Utilization

Christian Carpéné1,2, Francisco Les3,4, Guillermo Cásedas5

  • 1Institute of Metabolic and Cardiovascular Diseases, INSERM, UMR1048, Team 1, 31342 Toulouse, France. christian.carpene@inserm.fr.

Antioxidants (Basel, Switzerland)
|March 29, 2019
PubMed

Insights

Resveratrol rapidly limits glucose uptake and fat accumulation in adipocytes by counteracting insulin

Area of Science:

  • Metabolic Science
  • Nutritional Biochemistry
  • Pharmacology

Background:

  • Resveratrol shows promise in mitigating metabolic disease complications in animal models.
  • Prolonged resveratrol treatment in preadipocytes impairs adipogenesis.
  • Adipocytes play a key role in fat storage, influenced by insulin during post-prandial periods.

Purpose of the Study:

  • To investigate the short-term effects of resveratrol on glucose disposal within the gut-adipose tissue axis.
  • To understand how resveratrol limits glucose uptake and lipid incorporation in adipocytes.
  • To explore the mechanisms underlying resveratrol's antilipogenic effects.

Main Methods:

  • Assessed resveratrol's inhibitory capacity against α-glucosidase and pancreatic lipase.
  • Examined resveratrol's effect on glucose transport in mature adipocytes, including its interaction with insulin.
  • Investigated resveratrol's inhibition of glucose incorporation into lipids and its relation to membrane cholesterol.
  • Evaluated the role of semicarbazide-sensitive amine oxidase activity and compared resveratrol with other phytochemicals.

Main Results:

  • Resveratrol potently inhibits α-glucosidase activity more than pancreatic lipase.
  • Resveratrol rapidly reduces glucose transport in adipocytes, counteracting insulin and insulin-like lipogenic agents.
  • Resveratrol inhibits glucose incorporation into adipocyte lipids within two hours, independent of membrane cholesterol.
  • Resveratrol's antilipogenic effect is not mediated by semicarbazide-sensitive amine oxidases.
  • Caffeine and piceatannol also inhibit adipocyte lipogenesis, unlike other antioxidant phytochemicals.

Conclusions:

  • Resveratrol exhibits multiple early mechanisms to impede excessive fat accumulation.
  • Resveratrol's potent inhibition of glucose uptake and lipid synthesis in adipocytes suggests anti-obesity potential.
  • Further research into resveratrol and its derivatives is warranted for developing anti-obesity therapeutics.
Keywords:
adipose cellsamine oxidaseshydrogen peroxidelipogenesisobesitypolyphenols

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