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Updated: Jan 27, 2026

Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells
Published on: February 9, 2012
Lifetime Estimation for Multi-Phase Deteriorating Process with Random Abrupt Jumps.
Jianxun Zhang1, Xiaosheng Si2,3, Dangbo Du4
1Department of Automation, Xi'an Research Institute of High-Tech, Xi'an 710025, China. jx-zhang14@tsinghua.org.cn.
Estimating the lifetime of degrading systems with multi-phase trajectories and abrupt jumps is challenging. This study introduces a novel Wiener process-based model for accurate lifetime estimation using first passage time (FPT) analysis.
Area of Science:
- Reliability Engineering
- Stochastic Processes
- Degradation Modeling
Background:
- Degradation trajectories often exhibit multi-phase features with abrupt jumps due to changing operating conditions or physical mutations.
- Traditional lifetime estimation methods are inadequate for processes with such complex degradation patterns.
Purpose of the Study:
- To develop a robust method for estimating the lifetime of multi-phase degradation processes with abrupt jumps.
- To extend existing models to account for unit-to-unit variability and complex multi-phase behaviors.
Main Methods:
- Formulation of a multi-phase degradation model with jumps based on the Wiener process.
- Derivation of a closed-form expression for lifetime in a two-phase model with fixed jumps.
- Extension of the model to incorporate random effects and further phases.
- Development of a model identification method using Expectation Maximization (EM) algorithm and Bayesian rule.
Main Results:
- A novel Wiener process-based model effectively describes multi-phase degradation with abrupt jumps.
- Closed-form lifetime expressions were derived for simplified and extended cases.
- An effective model identification method was proposed for practical implementation.
Conclusions:
- The proposed approach provides a reliable framework for lifetime estimation in complex degradation scenarios.
- The methods are applicable to systems with unit-to-unit variability and multi-phase degradation patterns.
- Demonstrated utility through numerical case studies and a practical gyro example.
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