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Updated: Jan 27, 2026

Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells
Published on: February 9, 2012
Lifetime Estimation for Multi-Phase Deteriorating Process with Random Abrupt Jumps
Jianxun Zhang1, Xiaosheng Si2,3, Dangbo Du4
1Department of Automation, Xi'an Research Institute of High-Tech, Xi'an 710025, China. jx-zhang14@tsinghua.org.cn.
Abstract:
Owing to operating condition changing, physical mutation, and sudden shocks, degradation trajectories usually exhibit multi-phase features, and the abrupt jump often appears at the changing time, which makes the traditional methods of lifetime estimation unavailable. In this paper, we mainly focus on how to estimate the lifetime of the multi-phase degradation process with abrupt jumps at the change points under the concept of the first passage time (FPT). Firstly, a multi-phase degradation model with jumps based on the Wiener process is formulated to describe the multi-phase degradation pattern. Then, we attain the lifetime's closed-form expression for the two-phase model with fixed jump relying on the distribution of the degradation state at the change point. Furthermore, we continue to investigate the lifetime estimation of the degradation process with random effect caused by unit-to-unit variability and the multi-phase degradation process. We extend the results of the two-phase case with fixed parameters to these two cases. For better implementation, a model identification method with off-line and on-line parts based on Expectation Maximization (EM) algorithm and Bayesian rule is proposed. Finally, a numerical case study and a practical example of gyro are provided for illustration.
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