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Medicinal Herbs Effective Against Atherosclerosis: Classification According to Mechanism of Action
1Colleage of Pharmacy, Duksung Woman's University, Seoul 01369, Republic of Korea.
Insights
Natural compounds show promise in preventing and treating atherosclerosis, a major cause of death. This review explores effective natural compounds and their mechanisms against this arterial disease.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Natural Product Chemistry
Background:
- Atherosclerosis is a chronic, progressive arterial disease and a leading global cause of mortality.
- Pathologically, it involves cholesterol and fat deposition in the arterial wall, causing narrowing and reduced blood flow.
- Natural products have a long history in managing cardiovascular diseases.
Purpose of the Study:
- To review natural compounds utilized for atherosclerosis treatment and prevention.
- To summarize the mechanisms of action for these compounds based on current research.
Main Methods:
- Literature review of scientific studies on natural compounds and atherosclerosis.
- Analysis of research data on the efficacy and mechanisms of natural compounds.
Main Results:
- Identified various natural compounds with demonstrated anti-atherosclerotic properties.
- Detailed the specific molecular and cellular mechanisms through which these compounds act.
Conclusions:
- Natural compounds represent a significant therapeutic strategy for atherosclerosis.
- Further research into these compounds can lead to novel preventative and treatment options for cardiovascular disease.
Abstract:
Atherosclerosis is a widespread and chronic progressive arterial disease that has been regarded as one of the major causes of death worldwide. It is caused by the deposition of cholesterol, fats, and other substances in the tunica intima which leads to narrowing of the blood vessels, loss of elasticity, and arterial wall thickening, thus causing difficulty in blood flow. Natural products have been used as one of the most important strategies for the treatment and prevention of cardiovascular diseases for a long time. In recent decades, as interests in natural products including medicinal herbs have increased, many studies regarding natural compounds that are effective against atherosclerosis have been conducted. The purpose of this review is to provide a brief overview of the natural compounds that have been used for the treatment and prevention of atherosclerosis, and their mechanisms of action based on recent research.
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