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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
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Characterizing specific subgroups in patients with NAFLD: overweight vs obese phenotype
Rosa Martín Mateos1, Alina M Allen2
1Gastroenterología, Hospital Universitario Ramón y Cajal, España.
Revista Espanola De Enfermedades Digestivas
|March 29, 2019
Summary
Non-alcoholic fatty liver disease (NAFLD) is a global health issue affecting 25.2% of people. This review covers NAFLD
Area of Science:
- Gastroenterology and Hepatology
- Metabolic Syndrome Research
- Microbiome Studies
Background:
- Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease globally, impacting 25.2% of the population.
- NAFLD poses significant risks beyond liver conditions, including cirrhosis and hepatocellular carcinoma, and is linked to cardiovascular complications via metabolic syndrome.
- This special issue addresses critical NAFLD aspects, highlighting its broad health implications.
Discussion:
- Explores the characterization of fecal microbiota profiles in NAFLD patients.
- Examines the emerging role of bariatric endoscopy in managing NAFLD.
- Investigates the development and utility of pre-clinical models for NAFLD research.
Key Insights:
- Fecal microbiota analysis offers potential diagnostic or therapeutic targets for NAFLD.
- Bariatric endoscopy presents a novel approach for NAFLD intervention.
- Understanding epidemiological risk factors is crucial for differentiating Non-alcoholic steatohepatitis (NASH) and fibrosis progression.
Outlook:
- Future research should focus on translating microbiota findings into clinical practice.
- Further evaluation of bariatric endoscopy's long-term efficacy in NAFLD is warranted.
- Continued investigation into epidemiological factors will refine NAFLD prevention and treatment strategies.
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