Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cluster Sampling Method01:20

Cluster Sampling Method

14.3K
Appropriate sampling methods ensure that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
To choose a cluster sample, divide the population into clusters (groups) and then randomly select some of the clusters. All the members from these clusters are in the cluster sample. For example, if you randomly sample four departments from your...
14.3K
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

3.1K
After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
3.1K
Genetics of Speciation02:16

Genetics of Speciation

21.0K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.0K
What is Population Genetics?01:25

What is Population Genetics?

64.6K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.6K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.0K
Overview
80.0K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.1K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International Headache Week 2026: March 15-21.

The journal of headache and pain·2026
Same author

WHO's Global status report on neurology: mixed messages for people with headache disorders.

The journal of headache and pain·2026
Same author

Venous manometry triage in refractory idiopathic intracranial hypertension: imaging and criteria validity.

Journal of neurointerventional surgery·2025
Same author

Exploring medication-overuse and medication-overuse headache in cluster headache.

Cephalalgia : an international journal of headache·2025
Same author

Correction: The role of community pharmacists in managing common headache disorders, and their integration within structured headache services: position statement on behalf of the European Headache Federation (EHF) and Lifting The Burden (LTB: the Global Campaign against Headache), with the formal endorsement of the International Pharmaceutical federation.

The journal of headache and pain·2025
Same author

The role of community pharmacists in managing common headache disorders, and their integration within structured headache services: position statement on behalf of the European Headache Federation (EHF) and Lifting The Burden (LTB: the Global Campaign against Headache), with the formal endorsement of the International Pharmaceutical Federation.

The journal of headache and pain·2025

Related Experiment Video

Updated: Jan 27, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.7K

Genetics of cluster headache.

Kate F Gibson1, Anita Dos Santos1, Nunu Lund2

  • 11 Xenon Pharmaceuticals Inc, Burnaby, Canada.

Cephalalgia : an International Journal of Headache
|March 29, 2019
PubMed
Summary

Genetic studies reveal limited understanding of cluster headache susceptibility. While candidate gene research has identified potential links, larger genome-wide studies are needed for reproducible results and to uncover cluster headache causes.

Keywords:
GWASGeneticsmigraine

More Related Videos

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.7K
Computation of Atmospheric Concentrations of Molecular Clusters from ab initio Thermochemistry
12:11

Computation of Atmospheric Concentrations of Molecular Clusters from ab initio Thermochemistry

Published on: April 8, 2020

8.7K

Related Experiment Videos

Last Updated: Jan 27, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.7K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.7K
Computation of Atmospheric Concentrations of Molecular Clusters from ab initio Thermochemistry
12:11

Computation of Atmospheric Concentrations of Molecular Clusters from ab initio Thermochemistry

Published on: April 8, 2020

8.7K

Area of Science:

  • Genetics
  • Neurology
  • Headache Disorders

Background:

  • Cluster headache is a severe primary headache disorder with a suspected genetic component.
  • Previous family and twin studies suggest a genetic basis, but specific contributing variants remain largely unknown.
  • Understanding genetic susceptibility is crucial for unraveling the disorder's etiology.

Purpose of the Study:

  • To review human genetic studies investigating cluster headache.
  • To provide an overview of cluster headache pathophysiology.
  • To briefly review migraine genetics as a driver for candidate gene selection in cluster headache research.

Main Methods:

  • Conducted a literature search of the MEDLINE database using PubMed.
  • Identified and reviewed all human genetic studies related to cluster headache.
  • Examined candidate gene studies and genome-wide association studies (GWAS).

Main Results:

  • Candidate gene studies have dominated cluster headache genetic research.
  • Circadian rhythm genes (e.g., CLOCK, HCRTR2) and GWAS-identified genes (e.g., ADCYAP1R1, MME) have been investigated.
  • Many studied candidate genes show poor reproducibility.

Conclusions:

  • Current genetic findings for cluster headache lack robust reproducibility.
  • Larger, unbiased genetic studies like GWAS, exome, and whole genome sequencing are necessary.
  • These broader approaches may identify more reliable genetic candidates and clarify cluster headache causes.