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Mast cells in oral lichen planus
Journal of Oral Pathology
|May 1, 1986
Summary
Mast cells increase significantly in oral lichen planus, showing degranulation and altered morphology. These findings suggest mast cells play a role in attracting lymphocytes to the affected oral mucosa.
Area of Science:
- Oral pathology
- Immunology
- Cell biology
Background:
- Oral lichen planus (OLP) is a chronic inflammatory condition affecting oral mucosa.
- Mast cells are immune cells involved in inflammatory and allergic responses.
Purpose of the Study:
- To compare mast cell characteristics in OLP versus healthy oral mucosa.
- To investigate mast cell morphology and degranulation in OLP.
Main Methods:
- Biopsies from OLP and healthy oral mucosa were analyzed.
- Light and electron microscopy were used to examine mast cells.
- Statistical analysis was performed on mast cell counts.
Main Results:
- Significantly increased mast cell numbers were observed below the subepithelial infiltrate in OLP (p < 0.001).
- Mast cells within the deeper infiltrate exhibited altered granule morphology, consistent with degranulation.
- Ultrastructural changes indicated mast cell activation.
Conclusions:
- Mast cells are significantly increased and activated in oral lichen planus.
- Mast cell degranulation may contribute to the inflammatory infiltrate in OLP.
- Mast cells likely participate in recruiting lymphocytes to the OLP lesion.