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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Nursing Clinical Information System01:27

Nursing Clinical Information System

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Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

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Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
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Related Experiment Video

Updated: Jan 27, 2026

Metagenomic Analysis of Silage
08:43

Metagenomic Analysis of Silage

Published on: January 13, 2017

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Clinical metagenomics.

Charles Y Chiu1,2, Steven A Miller3

  • 1Department of Laboratory Medicine, University of California, San Francisco, CA, USA. charles.chiu@ucsf.edu.

Nature Reviews. Genetics
|March 29, 2019
PubMed
Summary
This summary is machine-generated.

Clinical metagenomic next-generation sequencing (mNGS) offers comprehensive analysis for diagnosing infectious diseases. This summary addresses challenges and solutions for implementing mNGS in clinical labs to improve patient care.

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Large-Scale Screens of Metagenomic Libraries
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Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples

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Related Experiment Videos

Last Updated: Jan 27, 2026

Metagenomic Analysis of Silage
08:43

Metagenomic Analysis of Silage

Published on: January 13, 2017

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Large-Scale Screens of Metagenomic Libraries
16:05

Large-Scale Screens of Metagenomic Libraries

Published on: May 28, 2007

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Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples
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Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples

Published on: December 22, 2014

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Area of Science:

  • Clinical diagnostics
  • Genomic medicine
  • Microbiology

Background:

  • Clinical metagenomic next-generation sequencing (mNGS) analyzes microbial and host genetic material.
  • mNGS is transitioning from research to clinical practice.
  • It impacts infectious disease diagnosis and treatment.

Purpose of the Study:

  • To highlight the implementation challenges of mNGS in clinical laboratories.
  • To propose solutions for maximizing mNGS's impact on patient care and public health.

Main Methods:

  • Focus on the practical aspects of clinical laboratory implementation.
  • Review of current applications and future potential.

Main Results:

  • mNGS has broad applications: antimicrobial resistance, microbiome analysis, transcriptomics, and oncology.
  • Implementation presents unique challenges in clinical settings.

Conclusions:

  • Addressing implementation challenges is crucial for realizing the full potential of mNGS.
  • Successful integration of mNGS will advance patient care and public health outcomes.