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Updated: Jan 27, 2026

Metagenomic Analysis of Silage
Published on: January 13, 2017
Clinical metagenomics
Charles Y Chiu1,2, Steven A Miller3
1Department of Laboratory Medicine, University of California, San Francisco, CA, USA. charles.chiu@ucsf.edu.
Abstract:
Clinical metagenomic next-generation sequencing (mNGS), the comprehensive analysis of microbial and host genetic material (DNA and RNA) in samples from patients, is rapidly moving from research to clinical laboratories. This emerging approach is changing how physicians diagnose and treat infectious disease, with applications spanning a wide range of areas, including antimicrobial resistance, the microbiome, human host gene expression (transcriptomics) and oncology. Here, we focus on the challenges of implementing mNGS in the clinical laboratory and address potential solutions for maximizing its impact on patient care and public health.
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