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miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years

Frank Tacke1, Martina E Spehlmann2, Mihael Vucur1

  • 1Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.

Mediators of Inflammation
|March 29, 2019
PubMed
Abstract

Insights

Circulating miR-155 serum levels are elevated in critical illness. Lower miR-155 levels in patients under 65 predict mortality, suggesting an age-specific prognostic biomarker for critical care.

Area of Science:

  • Biomarkers
  • Critical Care Medicine
  • Molecular Biology

Background:

  • MicroRNA-155 (miR-155) serum levels are altered in inflammatory and infectious diseases.
  • A potential role for miR-155 in aging and age-related diseases has been suggested.
  • Investigating miR-155's prognostic value in critical illness is warranted.

Purpose of the Study:

  • To analyze the age-dependent prognostic value of circulating miR-155 in critical illness.
  • To evaluate miR-155 as a serum-based biomarker for patient outcomes.
  • To determine if miR-155 levels correlate with disease severity or sepsis.

Main Methods:

  • Quantitative PCR (qPCR) was used to measure serum miR-155 concentrations.
  • A cohort of 218 critically ill patients and 76 healthy controls was studied.
  • Patients were stratified by age (younger than 65 years) for subgroup analysis.

Main Results:

  • Serum miR-155 levels were significantly elevated in critically ill patients compared to controls.
  • miR-155 levels were independent of disease severity, etiology, or sepsis presence.
  • In patients younger than 65, lower miR-155 levels accurately predicted mortality.

Conclusions:

  • Circulating miR-155 demonstrates an age-specific prognostic role in critical illness, particularly in patients under 65.
  • This study identifies the first age-dependent microRNA-based prognostic biomarker in human diseases.
  • miR-155 may serve as a valuable tool for predicting mortality in younger critically ill patients.

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