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Frailty Assessment in an Aging Mouse Model
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Protective effect of walnut on d-galactose-induced aging mouse model
Ji Liu1, Dan Chen2, Zukun Wang1
1School of Chinese Materia Medica Yunnan University of Traditional Chinese Medicine Kunming China.
Food Science & Nutrition
|March 29, 2019
Summary
Walnut seed coats (WSCs) show promise in combating aging symptoms induced by d-galactose in mice. These findings suggest WSCs can improve cognitive function and protect against liver damage, offering potential anti-aging benefits.
Area of Science:
- Gerontology
- Nutritional Science
- Oxidative Stress Research
Background:
- Oxidative stress and apoptosis are key factors in the aging process.
- d-galactose (gal) administration induces aging phenotypes and organ damage in mice.
- Walnuts are recognized for their potential health benefits.
Purpose of the Study:
- To investigate the antioxidative and anti-apoptotic effects of walnut components.
- To evaluate the efficacy of walnut in a d-galactose-induced mouse aging model.
- To elucidate the mechanisms underlying walnut's effects on aging.
Main Methods:
- Aging was induced in mice via daily subcutaneous injection of d-galactose for 8 weeks.
- Walnut samples were administered daily via intragastric gavage.
- Key parameters monitored included body weight, organ index, cognitive function, antioxidative enzyme activity, and liver function.
Main Results:
- Walnut kernel pellicles and seed coats improved learning and memory in aging mice.
- Walnut administration normalized antioxidative enzyme levels and reduced body weight.
- Walnut seed coats protected against hippocampus and liver damage.
Conclusions:
- Walnut seed coats (WSCs) demonstrate beneficial effects on d-galactose-induced brain aging, improving learning and memory.
- WSCs likely exert their effects by reducing oxidative damage and neuroinflammation.
- WSCs also provide a protective effect against liver damage in aging mice.
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