Brugada Syndrome: Progress in Genetics, Risk Stratification and Management

Area of Science:

• Cardiology
• Genetics
• Molecular Medicine

Background:

• Brugada syndrome (BrS) is a primary cause of sudden cardiac death in individuals with structurally normal hearts.
• Global prevalence is estimated at 0.05%, with higher incidence in Southeast Asian populations.
• First identified in 1992, understanding of BrS has evolved significantly.

Purpose of the Study:

• To review the advancements in understanding Brugada syndrome.
• To summarize progress in the clinical management of BrS.
• To highlight new therapeutic strategies and risk stratification methods.

Main Methods:

• Literature review of Brugada syndrome.
• Analysis of genetic and molecular mechanisms.
• Evaluation of current and emerging treatment modalities.

Main Results:

• Significant progress in understanding BrS genetics and molecular basis.
• Development of improved risk stratification tools.
• Emergence of novel therapies, including epicardial ablation.

Conclusions:

• Continued research into Brugada syndrome pathogenesis is essential.
• Clinical practice requires updated guidance based on new findings.
• Further studies are needed to refine patient management and therapeutic approaches.