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Obesity and Atrial Fibrillation: Epidemiology, Pathophysiology and Novel Therapeutic Opportunities

Vishal Vyas1,2,3, Pier Lambiase3,4

  • 1Barts and The London School of Medicine and Dentistry London, UK.

Arrhythmia & Electrophysiology Review
|March 29, 2019
PubMed

Insights

Obesity significantly increases the risk of atrial fibrillation (AF). Managing obesity is crucial for preventing and treating AF, offering new therapeutic avenues beyond traditional methods.

Area of Science:

  • Cardiology
  • Public Health
  • Endocrinology

Background:

  • Obesity is a global health crisis linked to numerous diseases.
  • Obesity is an independent risk factor for atrial fibrillation (AF) incidence and progression.
  • Current AF management strategies face challenges with rising costs and outcomes.

Purpose of the Study:

  • To review the epidemiological link between obesity and AF.
  • To explore the pathophysiology of obesity-induced arrhythmogenesis.
  • To discuss emerging therapeutic strategies for obesity and AF.

Main Methods:

  • Epidemiological data analysis.
  • Review of adipose tissue biology and its role in cardiac arrhythmias.
  • Synthesis of current research on obesity and AF management.

Main Results:

  • Established epidemiological association between obesity and AF.
  • Insights into how adipose tissue influences heart rhythm.
  • Evidence supporting obesity management as a key secondary prevention strategy for AF.

Conclusions:

  • Obesity is a critical, modifiable risk factor for AF.
  • Targeting obesity offers a promising approach to improve AF outcomes.
  • Future research should focus on novel obesity-focused interventions for AF.

Keywords:
Atrial fibrillationadiposityepicardial fatobesityobesity paradoxrisk factor management

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