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Updated: Jan 27, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
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Abrupt visual loss during anti-vascular endothelial growth factor treatment for type 3 neovascularization

Jae Hui Kim1, Young Suk Chang2, Jong Woo Kim1

  • 1Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul 150-034, Korea.

International Journal of Ophthalmology
|March 29, 2019
PubMed
Abstract

Insights

Abrupt visual loss affects 16.1% of patients receiving anti-vascular endothelial growth factor (VEGF) therapy for type 3 neovascularization, leading to significantly worse visual outcomes.

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Neovascularization

Background:

  • Type 3 neovascularization is a significant cause of vision loss.
  • Anti-vascular endothelial growth factor (VEGF) therapy is a common treatment for neovascular eye conditions.
  • Abrupt visual loss is a potential complication during anti-VEGF treatment.

Purpose of the Study:

  • To determine the incidence of abrupt visual loss in patients with type 3 neovascularization undergoing anti-VEGF treatment.
  • To identify factors associated with abrupt visual loss.
  • To compare visual acuity outcomes between patients with and without abrupt visual loss.

Main Methods:

  • Retrospective study of 137 eyes with newly diagnosed type 3 neovascularization treated with anti-VEGF therapy.
  • Abrupt visual loss defined as a loss of 5 or more lines of best-corrected visual acuity (BCVA).
  • Analysis of incidence, timing, associated factors, and final BCVA.

Main Results:

  • Abrupt visual loss occurred in 16.1% of eyes at a mean of 19.6 months post-diagnosis.
  • Associated factors included subretinal hemorrhage (50.0%), pigment epithelial detachment with fluid (36.4%), and retinal pigment epithelium tears (13.6%).
  • Eyes with abrupt visual loss had significantly worse final BCVA (logMAR 2.07) compared to those without (logMAR 1.00).

Conclusions:

  • Abrupt visual loss is a significant complication in 16.1% of type 3 neovascularization patients treated with anti-VEGF therapy.
  • This complication is linked to poor visual outcomes.
  • Further research is required to develop preventative strategies for abrupt visual loss.
Keywords:
age-related macular degenerationhemorrhagepigment epithelial detachmentretinal angiomatous proliferationtear in retinal pigment epitheliumtype 3 neovascularization

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