Related Experiment Video
Updated: Jan 27, 2026
10:13
Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
Published on: May 6, 2019
9.5K
Immunogenicity and Immunodominance in Antibody Responses
Monique Vogel1, Martin F Bachmann2,3
1Department of Rheumatology, Immunology and Allergology, University Hospital Bern, Sahlihaus 2, CH-3010, Bern, Switzerland.
Current Topics in Microbiology and Immunology
|March 29, 2019
Summary
Developing effective vaccines against challenging infectious agents requires overcoming hurdles like antigen variability. Novel strategies aim to induce robust antibody responses against fragile antigens for improved prophylactic vaccines.
Area of Science:
- Vaccinology
- Immunology
- Infectious Diseases
Background:
- Numerous vaccines exist, yet many pathogens lack effective prophylactic vaccines.
- Common challenges in vaccine design include highly variable surface antigens and the need for high antibody levels.
- Conserved epitopes are difficult to display immunogenically, and fragile antigens require specific strategies.
Purpose of the Study:
- To address the challenges in designing vaccines against pathogens with variable antigens.
- To explore methods for inducing high antibody responses against fragile antigens.
- To advance modern vaccinology by developing strategies for difficult-to-target infectious agents.
Main Methods:
- Investigating the use of conserved epitopes for vaccine design.
- Exploring the display of epitopes using live vectors or virus-like particles.
- Focusing on conformational display of antigens for immunogenicity.
Main Results:
- Identified conserved epitopes as a potential strategy for highly variable antigens.
- Demonstrated that live vectors and virus-like display can achieve high antibody titers.
- Highlighted the importance of conformational antigen display for immunogenicity.
Conclusions:
- Overcoming antigen variability and achieving high antibody titers are key goals in modern vaccinology.
- Novel display strategies are crucial for developing effective vaccines against challenging pathogens.
- Further research is needed to induce high antibody responses against fragile antigens for broad vaccine applicability.
Related Concept Videos
01:10Antibody Structure
65.5K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
65.5K
01:36Humoral Immune Responses
83.5K
Overview
83.5K
01:26Antibody Actions
2.4K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
2.4K
01:25Antibody Structure and Classes
8.5K
Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
8.5K
02:26Responses to Gravity and Touch
41.7K
Gravitropism: Plant Responses to Gravity
41.7K
02:41Responses to Drought and Flooding
12.0K
Water plays a significant role in the life cycle of plants. However, insufficient or excess of water can be detrimental and pose a serious threat to plants.
12.0K