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Experimental study of muscle permeability under various loading conditions
Iftah Nudel1, Or Hadas1, Gal deBotton2,3
1Department of Biomedical Engineering, Ben-Gurion University, 8410501, Beer-Sheva, Israel.
Biomechanics and Modeling in Mechanobiology
|March 29, 2019
Summary
Muscle tissue permeability decreases with compression and dehydration. Under physiological conditions, various muscle types exhibit similar permeability, suggesting a common interstitial fluid flow mechanism.
Area of Science:
- Biomedical Engineering
- Physiology
- Tissue Mechanics
Background:
- Muscle tissue permeability is vital in understanding diseases like compartment syndrome.
- Characterizing muscle permeability under loading conditions is crucial for physiological insights.
Purpose of the Study:
- To measure and characterize the permeability of various muscle tissues under different loading conditions.
- To investigate the impact of pre-compression and dehydration on muscle tissue permeability.
Main Methods:
- Development of a novel experimental apparatus utilizing the falling head method for permeability measurements.
- Design of a specialized sample holder for controlled pre-compression and directed fluid flow through tissue samples.
- Permeability measurements conducted on porcine, beef, chicken, and lamb muscle tissues.
Main Results:
- Muscle tissue permeability significantly decreases with increasing pre-compression.
- Dehydration of muscle tissue also leads to a notable decrease in permeability.
- Remarkably similar permeability values were observed across different muscle types within a physiological pressure range.
- Muscle permeability was quantified between 80 and 230 [Formula: see text] under physiological loading conditions.
Conclusions:
- Muscle permeability is governed by a common micro-mechanical mechanism related to interstitial space fluid flow.
- Pre-compression and dehydration are key factors influencing muscle tissue permeability.
- The findings provide essential data for understanding muscle physiology and pathophysiology.
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