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Total Synthesis of (-)-Daphenylline

Bo Xu1,2, Bingyang Wang1,2, Wen Xun1,2

  • 1State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou, 510530, China.

Angewandte Chemie (International Ed. in English)
|March 29, 2019
PubMed
Summary

A concise total synthesis of the Daphniphyllum alkaloid (-)-daphenylline was achieved in 19 steps. This study highlights key stereoselective reactions for constructing the complex tetracyclic core and DF ring system.

Keywords:
Diels-Alder cycloadditionFriedel-Crafts alkylationalkaloidsdaphenyllinetotal synthesis

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