Related Experiment Video
Updated: Jan 27, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
The crisis of ethics and integrity in Evidence Based Medicine and scientific practice
1Independent Consultant Researcher and Teacher in Bioethics and Public Health, 310 Prabhu Darshan, 31, Swatantrya Sainik Nagar, Andheri West, Mumbai 400 058, India., amar.jesani@gmail.com.
Insights
The Cochrane Collaboration faced a crisis after expelling a founder member, revealing fundamental disagreements in Evidence-Based Medicine approaches. This event highlighted long-standing issues within the organization, bringing them into public view.
Area of Science:
- Medical Research Methodology
- Health Policy and Management
Background:
- The issue addresses the recent crisis within Cochrane, formerly the Cochrane Collaboration.
- Key events include the expulsion of founder member Peter Gotzsche and subsequent resignations.
Discussion:
- The crisis is presented not as a simple organizational dispute.
- It signifies deeper, long-standing differences in the approach to Evidence-Based Medicine.
Key Insights:
- The expulsion of Peter Gotzsche served as a catalyst, bringing underlying tensions to the forefront.
- Fundamental disagreements regarding Evidence-Based Medicine principles are central to the conflict.
Outlook:
- The public domain is now focused on these critical issues within Cochrane.
- Further examination of these differences is warranted for the future of Evidence-Based Medicine.
Abstract:
This issue of IJME carries three essays and a letter on the current crisis in Cochrane, earlier known as the Cochrane Collaboration. Cochrane expelled one of its founder members, Peter Gotzsche, on September 13, 2018, and in protest, four other Governing Board Members resigned. The essays show that what happened was not merely a clash within an organisation, but involved some basic differences on approach to Evidence Based Medicine. While these issues had been simmering for a long time, the expulsion brought them sharply into focus in the public domain.
Related Concept Videos
Ethics in Research
The Scientific Method
The Scientific Method
Generally, predictions are tested using carefully-designed experiments. Based on the outcome of these...
The Scientific Method
The Evidence for Evolution
Scientific Laws and Theories

