Fetal cardiac intervention for right sided heart disease: Pulmonary atresia with intact ventricular septum

Area of Science:

• Cardiology
• Pediatric Medicine
• Prenatal Medicine

Background:

• Congenital heart disease (CHD) is the most common birth defect, often requiring lifelong medical care.
• Advances in ultrasound and understanding of CHD progression enable in utero interventions.
• Early intervention can guide the developing cardiovascular system toward a normal trajectory, reducing morbidity and mortality.

Purpose of the Study:

• To evaluate the efficacy of fetal cardiac intervention (FCI) in managing congenital heart defects.
• To assess the potential of FCI in alleviating both left and right ventricular dysfunction.
• To explore the expansion of FCI for improved postnatal adaptation and long-term function in children with CHD.

Main Methods:

• Utilizes advanced ultrasound technology for in utero diagnosis and monitoring of fetal cardiac conditions.
• Implements early-stage interventions targeting the fetal cardiovascular system.
• Focuses on alleviating ventricular dysfunction through prenatal procedures.

Main Results:

• Fetal cardiac intervention has demonstrated success in alleviating left ventricular dysfunction.
• Remarkably positive outcomes have been observed for families undergoing FCI.
• Preliminary results suggest FCI may also be effective for right ventricular dysfunction.

Conclusions:

• Fetal cardiac intervention is a promising approach for managing congenital heart defects.
• Early intervention in utero can significantly improve cardiovascular development and reduce negative postnatal consequences.
• Expanding FCI holds potential for better long-term function and adaptation for a wider range of children with CHD.