Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

803
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
803
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

1.7K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.7K
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

1.6K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.6K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

759
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
759
Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)01:16

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

3.1K
Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
3.1K
Actin Polymerization01:42

Actin Polymerization

8.4K
Actin polymerization occurs through the head-to-tail association of binding sites on monomeric actin or G-actin to form filamentous or F-actin. The polymerization can be divided into three phases ̶  nucleation, elongation, and steady-state phase.
The nucleation phase involves forming a stable nucleus consisting of three actin monomers to form a new actin filament. Actin-binding proteins such as formins and Arp2/3 complex help filament growth post-nucleation. The Formins form straight...
8.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nanoparticle-in-microparticle oral delivery system based on drug-loaded polymeric micelles.

Chemical communications (Cambridge, England)·2026
Same author

Exploring the therapeutic potential of cannabidiol in soft tissue wound healing: Delivery strategies and anti-inflammatory pathways.

Acta pharmaceutica Sinica. B·2026
Same author

Nose-to-brain administration of cannabidiol-loaded polymeric micelles improves the core behavioral symptoms of autism spectrum disorder.

Bioactive materials·2026
Same author

Autonomous Hydrogel Actuators Programmed by Endogenous Biochemical Logic for Dual-Stage Morphing and Drug Release.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Biopharmaceutical evaluation of benznidazole-loaded microparticles: In vitro and in vivo studies.

International journal of pharmaceutics·2025
Same author

Natural Powerhouse Duo: Hierarchical Levan Hydrogels with Nanoencapsulated Cannabidiol as Local Delivery Systems.

Pharmaceutical research·2025

Related Experiment Video

Updated: Jan 27, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.8K

Polymeric Hydrogels as Technology Platform for Drug Delivery Applications.

Alejandro Sosnik1, Katia P Seremeta2,3

  • 1Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology, Technion City, Haifa, 3200003, Israel. alesosnik@gmail.com.

Gels (Basel, Switzerland)
|March 29, 2019
PubMed
Summary

Hydrogels offer versatile drug delivery options for various administration routes, enhancing patient compliance and therapeutic effects. This review focuses on their applications, particularly via mucosal routes for targeted treatments.

Keywords:
bioadhesion and mucoadhesiondrug deliveryhydrogelsocular deliveryoral deliveryrectal deliverytopical deliverytransdermal deliveryvaginal delivery

More Related Videos

An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion
08:29

An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion

Published on: March 31, 2022

4.9K
Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications
10:18

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications

Published on: May 17, 2022

6.7K

Related Experiment Videos

Last Updated: Jan 27, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.8K
An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion
08:29

An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion

Published on: March 31, 2022

4.9K
Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications
10:18

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications

Published on: May 17, 2022

6.7K

Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biomedical Engineering

Background:

  • Hydrogels are versatile materials extensively utilized in drug delivery systems.
  • Their tunable composition and adaptability to diverse administration routes (parenteral and non-parenteral) are key advantages.
  • Bioadhesive or mucoadhesive properties can prolong residence time at administration sites, improving therapeutic outcomes.

Purpose of the Study:

  • To provide an overview of recent hydrogel applications in drug delivery.
  • To emphasize the utilization of hydrogels for mucosal drug delivery routes.
  • To highlight the benefits of hydrogels in enhancing patient compliance and achieving sustained therapeutic effects.

Main Methods:

  • Review of current scientific literature on hydrogel applications in drug delivery.
  • Focus on studies employing parenteral, oral, topical, vaginal, and nasal administration routes.
  • Analysis of hydrogel properties relevant to drug release kinetics and therapeutic efficacy.

Main Results:

  • Hydrogels demonstrate significant potential in local and systemic therapies via various routes, including wound dressings and patches.
  • Specific applications in vaginal and nasal cavities show promise for local treatment and nose-to-brain drug delivery.
  • Hydrogels effectively improve patient compliance and enable long-term therapeutic effects.

Conclusions:

  • Hydrogels are highly adaptable platforms for advanced drug delivery.
  • Mucosal routes represent a significant area for hydrogel-based therapeutic strategies.
  • The versatility and efficacy of hydrogels underscore their importance in modern medicine.