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Bacteriotherapy in children with recurrent upper respiratory tract infections

V Tarantino1, V Savaia, R D'Agostino

  • 1Dipartimento Testa-Collo e Neuroscienze - IRCCS Istituto Giannina Gaslini, Genoa, Italy gio.cip@libero.it.

European Review for Medical and Pharmacological Sciences
|March 29, 2019
PubMed

Insights

Bacteriotherapy using a nasal spray significantly reduced recurrent upper-airway infections (UI) in children. This treatment also decreased school and work absences, offering a potential preventive strategy for frequent infections.

Area of Science:

  • Pediatric infectious diseases
  • Microbiome therapeutics
  • Respiratory health

Background:

  • Recurrent upper-airway infections (UI) in children impose significant social and economic burdens on families.
  • Bacteriotherapy presents a novel approach to potentially prevent recurrent infections by modulating the microbial environment.

Purpose of the Study:

  • To evaluate the efficacy of bacteriotherapy in preventing recurrent upper-airway infections (UI) in children.
  • To assess the impact of bacteriotherapy on school and work absenteeism related to UI.

Main Methods:

  • An open-label study involving 80 children with recurrent UI.
  • Treatment administered via a nasal spray containing Streptococcus salivarius 24SMB and Streptococcus oralis 89a for one week, repeated for three months.
  • Outcomes measured included the number of UI and associated school/work absences, compared to the previous year.

Main Results:

  • A significant reduction in the mean number of UI from 5.98 to 2.75 post-treatment (p<0.0001).
  • Significant decreases in school absences (4.50 to 2.80, p<0.0001) and work absences (2.33 to 1.48, p<0.0001) were observed.
  • The results indicate a strong positive effect of the bacteriotherapy intervention.

Conclusions:

  • Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray shows promise in preventing recurrent UI in pediatric populations.
  • This preliminary study suggests a viable therapeutic option for managing recurrent respiratory infections in children.
  • Further research is warranted to confirm these findings in larger, controlled trials.
Abstract

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