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Updated: Jan 27, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Electrooxidative and Regioselective C-H Azolation of Phenol and Aniline Derivatives
Pengju Feng1, Guojian Ma1, Xiaoguang Chen1
1Department of Chemistry, Jinan University, Guangzhou, 510632, China.
Abstract:
A general and practical protocol was developed for the regioselective C-H azolation of phenol and aniline derivatives by electrooxidative cross-coupling. The reaction occurs under metal-, oxidant-, and reagent-free conditions, allowing access to a wide variety of synthetically useful heteroarene derivatives. The reaction also tolerates a broad range of functional groups and is amenable to gram-scale synthesis. Finally, a preliminary mechanistic study indicated that a radical-radical-combination pathway might be involved in the coupling reaction.
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