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Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections
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Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections

Published on: October 31, 2017

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Bacterial sexually transmitted infections

Susanne Buder1, Helmut Schöfer2, Thomas Meyer3

  • 1German Reference Laboratory for Gonococci, Department of Dermatology and Venerology, Vivantes Hospital, Berlin, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|March 29, 2019
PubMed

Insights

Bacterial sexually transmitted infections (STIs) are rising globally and in Germany, with increasing antibiotic resistance complicating treatment. Rapid PCR methods aid detection, but drug resistance in gonorrhea and Mycoplasma genitalium necessitates sensitivity testing.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Global and German incidence of bacterial sexually transmitted infections (STIs) is increasing.
  • Non-notifiable STIs like gonorrhea, Chlamydia trachomatis, and Mycoplasma genitalium show rising trends.
  • Varied clinical presentations, including asymptomatic cases, contribute to STI spread.

Purpose of the Study:

  • To highlight the increasing incidence of bacterial STIs in Germany.
  • To emphasize the diagnostic capabilities of new real-time multiplex PCR methods.
  • To address the growing challenge of antibiotic resistance in common STI pathogens.

Main Methods:

  • Review of recent trends in bacterial STI incidence.
  • Discussion of diagnostic advancements using real-time multiplex PCR.
  • Analysis of antibiotic resistance patterns in Neisseria gonorrhoeae and Mycoplasma genitalium.

Main Results:

  • Significant increase in reported syphilis cases in Germany.
  • Uptick in non-notifiable STIs, including gonorrhea, Chlamydia trachomatis, and Mycoplasma genitalium.
  • Emergence of high-level antibiotic resistance in Neisseria gonorrhoeae and Mycoplasma genitalium.

Conclusions:

  • Rapid PCR methods offer effective STI pathogen detection.
  • Antibiotic resistance in N. gonorrhoeae and M. genitalium complicates treatment strategies.
  • Sensitivity testing is crucial for N. gonorrhoeae alongside NAATs due to resistance.

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