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Insight into Novel Treatment for Cognitive Dysfunctions across Disorders
Thomas D Prevot1,2, Guanguan Li3, James M Cook3
1Campbell Family Mental Health Research Institute , Centre for Addiction and Mental Health , Toronto , ON M5T 1R8 , Canada.
Abstract:
Cognitive dysfunctions, including impaired attention, learning, memory, and problem solving, occur in psychiatric diseases, such as depression, and are a hallmark of aging. Altered GABAergic signaling is similarly reported across these conditions, but therapeutic approaches are limited by pan-receptor activities of benzodiazepine-like ligands. α5-GABA-A receptor-preferring ligands uncover novel therapeutics for cognitive dysfunctions.
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