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Development of a new bed-side-test assessing conditioned pain modulation: a test-retest reliability study
Jesper Bie Larsen1,2, Pascal Madeleine2, Lars Arendt-Nielsen3
1Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg East, Denmark.
Scandinavian Journal of Pain
|March 29, 2019
Summary
This study developed a bedside test for conditioned pain modulation (CPM) in healthy volunteers. While feasible and reliable for inducing stimuli, it did not detect significant CPM effects, necessitating further research.
Area of Science:
- Pain Research
- Neuroscience
- Clinical Diagnostics
Background:
- Conditioned pain modulation (CPM) is crucial in pain research but challenging to implement clinically.
- A fast, reliable clinical CPM assessment could enhance pain patient profiling.
Purpose of the Study:
- To develop and assess the feasibility and reliability of a novel bedside test for CPM.
- To evaluate different test protocols for CPM assessment in healthy individuals.
Main Methods:
- A test-retest reliability and methodological development study involving 51 healthy subjects.
- Utilized a handheld pressure algometer for phasic test stimuli and clamps for tonic conditioning stimuli.
- Evaluated four distinct test protocols, with one assessed for reliability.
Main Results:
- The developed bedside test was feasible and easy to use in healthy volunteers.
- No significant conditioned pain modulation (CPM) effects were detected across protocols.
- Good relative reliability (ICC: 0.67-0.72) was observed for the pressure algometer, but absolute reliability was limited.
Conclusions:
- The pressure algometer is a reproducible tool for inducing phasic stimuli in CPM testing.
- The current bedside test protocol did not yield significant CPM effects, precluding recommendations for clinical use.
- Further research is needed to optimize stimuli and investigate CPM in patient populations.
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