Related Experiment Video
Updated: Jan 27, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Headache in Postoperative Isolated Sagittal Synostosis
Stephanie D C van de Beeten1, Irene M J Mathijssen1, Nathalie W Kamst1
1From the Department of Plastic and Reconstructive Surgery and Hand Surgery and Department of Neurosurgery, Dutch Craniofacial Centre, Erasmus University Medical Center.
Insights
Frequent headaches in children after sagittal synostosis surgery are linked to the type of operation and head size. Regular head circumference measurements and headache monitoring are recommended for these patients.
Area of Science:
- Pediatric Neurosurgery
- Craniofacial Surgery
- Ophthalmology
Background:
- Sagittal synostosis is a condition requiring surgical correction in children.
- Headaches and signs of intracranial hypertension can occur post-surgery.
- Understanding headache triggers is crucial for patient management.
Purpose of the Study:
- To investigate the relationship between headaches and intracranial hypertension signs in children post-sagittal synostosis surgery.
- To identify predictors of frequent headaches in this patient population.
Main Methods:
- A cohort of 94 children (6-18 years) with sagittal synostosis were assessed.
- Data collected included headache frequency, surgical approach (frontobiparietal remodeling vs. extended strip craniotomy), funduscopy, OCT, occipitofrontal head circumference, and vertex bulge.
- Retrospective data analysis was performed.
Main Results:
- Univariate analysis indicated that extended strip craniotomy, ophthalmic signs, and smaller occipitofrontal head circumference correlated with increased headache frequency.
- Multivariate analysis confirmed that surgical type and occipitofrontal head circumference at follow-up were significant independent predictors of headaches.
Conclusions:
- Frequent headaches in children after sagittal synostosis correction are independently associated with surgical approach and occipitofrontal head circumference.
- Ophthalmic findings like papilledema may contribute to headaches.
- Routine measurement of occipitofrontal head circumference and inquiry about headaches are recommended during follow-up.
Background:
This study investigates the relationship between headache and the occurrence of signs associated with intracranial hypertension such as ophthalmic signs, restricted skull growth, and a vertex bulge in children who were operated on for sagittal synostosis.
Methods:
A total of 94 patients (aged 6 to 18 years) with sagittal synostosis were asked to indicate their headache frequency. Based on their age at referral, the patients had undergone either frontobiparietal remodeling or an extended strip craniotomy. Data on funduscopy, optical coherence tomography, occipitofrontal head circumference, and presence of vertex bulge on radiography were collected retrospectively.
Results:
Univariate analysis showed that extended strip craniotomy, the occurrence of ophthalmic signs, and a smaller occipitofrontal head circumference at last follow-up were related to more frequent headaches (p = 0.01, p = 0.04, and p < 0.01, respectively). On multivariate analysis, only type of surgery and occipitofrontal head circumference at last follow-up remained significant predictors (p = 0.04 and p < 0.01, respectively).
Conclusions:
Although the reported rate of frequent headaches in this study is within the norm reported for the normal population, this study shows that after correction for sagittal craniosynostosis, frequent headaches are independently related to type of surgery and to occipitofrontal head circumference at last follow-up. Headaches in the sagittal craniosynostosis population may be related to papilledema and/or an increased total retinal thickness. Therefore, the authors recommend that occipitofrontal head circumference be routinely measured and that patients be asked about the occurrence and frequency of headaches during their checkup at the clinic.
Clinical Question/Level Of Evidence:
Therapeutic, III.
Related Concept Videos
Peripheral Artery Disease V: Postoperative Nursing Management
DNA Isolation
DNA Isolation
Overview Of Cell Separation And Isolation
Cyclic Processes And Isolated Systems
In the case of a non-isolated system, the change in the internal energy is zero only if the process is cyclic. A thermodynamic process is considered cyclic if the system undergoes a series of changes and returns to its initial state.
Consider a cyclic process that returns to its initial state, undergoing a four-step process. The heat transfer along each...
Techniques for Isolation of Pure Cultures

