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Pediatric Celiac Disease and Eosinophilic Esophagitis: Outcome of Dietary Therapy
Tiffany Patton1, Ankur Chugh2, Leena Padhye3
1Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Comer Children's Hospital, University of Chicago Medical Center, Chicago, IL.
Insights
Pediatric patients with celiac disease (CeD) and eosinophilic esophagitis (EoE) often require dietary changes. This study found soy is well tolerated, suggesting it as a first-line dietary reintroduction for managing both conditions.
Area of Science:
- Gastroenterology
- Pediatric Medicine
- Immunology
Background:
- Concomitant celiac disease (CeD) and eosinophilic esophagitis (EoE) are increasingly diagnosed in children.
- Dietary interventions are primary treatments for both CeD and EoE.
Purpose of the Study:
- To evaluate the effectiveness of dietary interventions in pediatric patients with co-occurring CeD and EoE.
- To assess the histologic outcomes of esophageal eosinophilia in response to dietary management.
Main Methods:
- Retrospective review of pediatric patient records with confirmed CeD and EoE.
- Analysis of dietary therapy and esophageal histologic response to treatment.
Main Results:
- Of 22 pediatric patients with CeD and EoE, 17 underwent repeat biopsies.
- An exclusive gluten-free diet led to resolution in 23.5%, while 59% required additional food eliminations.
- Soy reintroduction showed a 100% success rate in this cohort.
Conclusions:
- Dietary management is crucial for pediatric patients with concurrent CeD and EoE.
- Soy appears to be a well-tolerated food, making it a potential first choice for elimination or reintroduction diets.
Objective:
The coexistence of celiac disease (CeD) and eosinophilic esophagitis (EoE) in pediatric patients has been increasingly recognized. In the current study, we have aimed to assess the outcomes of therapeutic dietary interventions in a cohort of pediatric patients with CeD and EoE.
Methods:
Pediatric patient records obtained from the University of Chicago Celiac Center Database from August 2008 to July 2013 were reviewed. Information was collected on patients with concomitant CeD and EoE regarding age, sex, dates of diagnoses, presenting symptoms, length of symptoms before diagnosis, familial and personal atopic history, dietary therapy, and esophageal histologic response to dietary therapy.
Results:
A total of 350 records of patients with CeD were reviewed. Twenty-two (6.3%) had a confirmed diagnosis of CeD and EoE, 17 had repeat biopsies. Four of 17 (23.5%) had resolution of esophageal eosinophilia on an exclusive gluten-free diet, 10 of 17 (59%) required additional eliminations to show histologic resolution, 1 of 17 (6%) had not reached histological remission, and 2 of 17 (12%) were lost to follow-up. Success rates of single food reintroductions were: soy 5 of 5 (100%), eggs 3 of 5 (60%), dairy 3 of 7 (43%), nuts 2 of 4 (50%), and fish 2 of 4 (50%).
Conclusions:
To our knowledge, this is the largest pediatric study to assess the histologic outcome of EoE-associated esophageal eosinophilia in response to dietary management of pediatric patients with concomitant CeD and EoE. We demonstrate that soy is well tolerated in this cohort, and suggest that reintroducing this food first, or trialing a soy-inclusive elimination diet is a viable strategy.
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