Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intellectual Disability01:29

Intellectual Disability

702
Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
702
Limits on Trigonometric Functions01:25

Limits on Trigonometric Functions

59
Limits on Trigonometric FunctionsThe limits of trigonometric functions play a fundamental role in calculus, particularly in defining derivatives. One of the most important results is:which is important for differentiating trigonometric functions and is widely applied in mathematical analysis and physics.Geometric IntuitionA common approach to proving this result involves analyzing a sector of a unit circle with an angle subtended at the center. Since the arc length is numerically equal to the...
59
Difference from Background: Limit of Detection01:05

Difference from Background: Limit of Detection

8.2K
The limit of detection (LOD) is the smallest amount of analyte that can be distinguished from the background noise. The LOD value corresponds to the concentration at which the analyte signal is three times larger than the standard deviation of the blank signal. Below this value, the analyte signal cannot be differentiated from the background noise. It is calculated by dividing the calibration slope by 3 times the standard deviation of the blank signals.
The LOD indicates the presence or absence...
8.2K
Reliability and Validity01:29

Reliability and Validity

13.8K
Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
13.8K
Limiting Reactant02:27

Limiting Reactant

69.7K
The relative amounts of reactants and products represented in a balanced chemical equation are often referred to as stoichiometric amounts. However, in reality, the reactants are not always present in the stoichiometric amounts indicated by the balanced equation.
69.7K
The Number e as a Limit01:29

The Number e as a Limit

75
The number e is a fundamental constant in calculus, playing a central role in describing continuous change, particularly exponential growth. It is most naturally defined through its relationship with the natural logarithm, which is the inverse of the exponential function with base e. This relationship allows e to be characterized using basic principles of differentiation rather than as an arbitrary numerical constant.A key property of the natural logarithm function, ln x, is that its derivative...
75

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Digital Platform Engagement by Healthcare Professionals on Patient Adherence to Recombinant Human Growth Hormone Therapy.

Studies in health technology and informatics·2026
Same author

Foamy microglia link oxylipins to disease progression in multiple sclerosis.

Nature neuroscience·2026
Same author

Socioeconomic inequity in extreme outcomes within very pre-term and/or very low birthweight infants: evidence from multi-national cohorts.

Frontiers in public health·2026
Same author

Severe neonatal complications and long-term health-related quality of life in very preterm and/or very low birth weight survivors: evidence from the Dutch Project on preterm and small for gestational age cohort.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2026
Same author

Comparison of early growth and development in very preterm children in the Netherlands between the 1980s and 2000s.

BMC pediatrics·2026
Same author

Adherence to growth hormone treatment in the transition age: A prospective observational multicenter study.

Journal of the Endocrine Society·2026

Related Experiment Video

Updated: Jan 27, 2026

Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA
10:21

Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA

Published on: February 23, 2024

3.7K

Predictive validity of developmental milestones for detecting limited intellectual functioning.

Eline Vlasblom1, Magda M Boere-Boonekamp2, Esther Hafkamp-de Groen3

  • 1Department of Child Health, TNO, Leiden, The Netherlands.

Plos One
|March 29, 2019
PubMed
Summary

Nine early developmental milestones, such as babbling by 12 months and walking by 24 months, can predict limited intellectual functioning in children. These milestones offer valuable insights for early identification and intervention in child health care.

More Related Videos

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

69.7K
Characterization and Functional Prediction of Bacteria in Ovarian Tissues
10:12

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Published on: October 23, 2021

3.2K

Related Experiment Videos

Last Updated: Jan 27, 2026

Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA
10:21

Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA

Published on: February 23, 2024

3.7K
A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

69.7K
Characterization and Functional Prediction of Bacteria in Ovarian Tissues
10:12

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Published on: October 23, 2021

3.2K

Area of Science:

  • Child Development
  • Developmental Psychology
  • Pediatric Health

Background:

  • Developmental milestones are crucial in pediatric care but their predictive validity is often unassessed.
  • Early identification of limited intellectual functioning is essential for timely intervention.

Purpose of the Study:

  • To assess the predictive validity of 75 developmental milestones for identifying limited intellectual functioning before age 4.
  • To identify specific milestones with high predictive power for intellectual disability.

Main Methods:

  • A case-control study involving 148 children with limited intellectual functioning (cases) and 300 controls.
  • Retrieved developmental milestone data from Child Healthcare files for analysis.
  • Calculated sensitivity, specificity, and likelihood ratios (LR+) for each milestone.

Main Results:

  • Nine developmental milestones demonstrated significant predictive validity (LR+ > 10) for limited intellectual functioning.
  • Key milestones include early speech and motor skills (e.g., babbling at 12 months, walking at 24 months, sentences at 36 months).
  • These milestones showed high specificity (95-100%) and moderate sensitivity (8-54%), improving with combined analysis.

Conclusions:

  • Specific early developmental milestones possess substantial predictive validity for identifying children at risk of limited intellectual functioning.
  • These validated milestones can aid healthcare providers in early detection and support for affected children.