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Juxtasomal Biocytin Labeling to Study the Structure-function Relationship of Individual Cortical Neurons
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Current understanding of cortical structure and function in migraine.
Else A Tolner1, Shih-Pin Chen2,3,4, Katharina Eikermann-Haerter5
1Departments of Neurology and Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Cephalalgia : an International Journal of Headache
|March 30, 2019
Summary
Migraine involves changes in brain cortex structure and function, impacting pain perception and attack initiation. These cortical alterations contribute to migraine susceptibility and chronification.
Area of Science:
- Neuroscience
- Neurology
Background:
- Migraine is a complex neurological disorder.
- The role of the cerebral cortex in migraine pathophysiology is increasingly recognized.
Purpose of the Study:
- To review and discuss the existing literature on the involvement of cortical structure and function in migraine.
Main Methods:
- Literature review and synthesis of findings on cortical morphology and function in migraine.
Main Results:
- Structural and functional cortical changes are linked to migraine susceptibility.
- Cortical spreading depolarization is implicated in migraine aura.
- The cortex plays a role in head pain perception and sensory processing during migraine.
Conclusions:
- Cortical dysfunction contributes to migraine initiation, recurrence, and chronification.
- Interactions between cortical and subcortical networks are crucial.
- Further research is needed on underlying mechanisms and therapeutic implications.
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