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Updated: Jan 27, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
Published on: May 2, 2025
Wound Healing In Surgery for Trauma (WHIST): statistical analysis plan for a randomised controlled trial comparing
Ruth Knight1, Louise M Spoors2, Matthew L Costa2
1Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Oxford, OX3 7LD, UK. ruth.knight@csm.ox.ac.uk.
Background:
In the context of major trauma, the rate of wound infection in surgical incisions created during fracture fixation amongst patients with closed high-energy injuries is high. One of the factors which may reduce the risk of surgical site infection is the type of dressing applied over the closed incision. The WHIST trial evaluates the effects of negative-pressure wound therapy (NPWT) compared with standard dressings.
Methods/Design:
The WHIST trial is a multicentre, parallel group, randomised controlled trial. The primary outcome is the rate of deep surgical site infection at 30 days after major trauma. Secondary outcomes are measured at 3 and 6 months post-randomisation and include the Disability Rating Index, the EuroQoL EQ-5D-5 L, the Doleur Neuropathique Questionnaire, a patient-reported scar assessment, and record of complications. The analysis approaches for the primary and secondary outcomes are described here, as are the descriptive statistics which will be reported. The full WHIST protocol has already been published.
Discussion:
This paper provides details of the planned statistical analyses for this trial and will reduce the risks of outcome reporting bias and data driven results.
Trial Registration:
International Standard Randomised Controlled Trials database, ISRCTN12702354 . Registered on 9 December 2015.
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