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Updated: Jan 27, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Risk of digital ulcers occurrence in systemic sclerosis: a cross-sectional study
Alex Magno Coelho Horimoto1, Albert Schiaveto de Souza2, Silvia Helena Rodrigues3
1Rheumatology Division, Universidade Federal do Mato Grosso do Sul (UFMS), Av. Senador Filinto Muller s/n°, Campo Grande, MS, Mato Grosso, do Sul, 79080-190, Brazil. clinicaactivite@gmail.com.
Background/Objective:
Digital ulcers (DUs) represent a frequent complication of systemic sclerosis (SSc). The aim of this study was to evaluate clinical, serological and capillaroscopy features that are associated with DUs in patients with SSc.
Methods:
In this bicentric cross-sectional study, 70 patients with SSc were consecutively selected from March 2016 to April 2017. Demographic and clinical features, including the presence of active DUs, were collected. Videocapillaroscopy was performed in all patients.
Results:
Among the 70 patients included (mean age of 46.8 years, mean disease duration of 9.41 years), 14 (20%) had active DUs. Based on multivariate analysis, the presence of anti-Scl-70 antibodies, the HAQ-DI score, and the capillary loss score were independently associated with DUs with odds ratios of 7.96 (95% CI 1.32-47.99), 55.77 (95% CI 1.76-1764.28), and 16.66 (95% CI 2.07-133.81), respectively.
Conclusions:
The presence of avascular areas in capillaroscopy, elevation of HAQ-DI score and anti-Scl-70 antibodies were independent factors associated with DUs in patients with SSc.
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