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Primary acquired gastric outlet obstruction in children: A retrospective single center study
Yasir Ahmad Lone1, Danish Hushain1, Rajendra Singh Chana1
1Dept. of Pediatric Surgery, Jawaharlal Nehru Medical College, Aligarh Muslim University, UP, India.
Insights
Primary acquired gastric outlet obstruction (GOO) is rare in older children but presents with nonbilious vomiting. Surgical intervention, like gastrojejunostomy, offers a curative solution for this condition.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Clinical Case Series
Background:
- Idiopathic hypertrophic pyloric stenosis is the most common cause of gastric outlet obstruction (GOO) in infants.
- Late-onset pyloric stenosis beyond infancy is rare, and its etiology is poorly understood.
Purpose of the Study:
- To report the experience of managing 5 cases of primary acquired GOO in older children.
- To describe similarities and differences in management within this patient population.
Main Methods:
- Retrospective single-center study.
- Analysis of 5 patients with primary acquired GOO between July 2014 and June 2018.
- Review of clinical presentation, diagnostic workup, and surgical outcomes.
Main Results:
- Patients ranged from 3 to 6 years old, with one female.
- All presented with recurrent, nonbilious vomiting and failure to thrive.
- Diagnostic imaging showed a dilated stomach and delayed gastric emptying; surgery (retrocolic gastrojejunostomy) was curative in all cases.
Conclusions:
- Primary acquired GOO should be considered in older children with nonbilious vomiting and failure to thrive.
- Prompt surgical intervention is crucial for adequate nutrition and development.
- Further research is needed to understand the pathophysiology and guide prevention/treatment.
Background/ Purpose:
Idiopathic hypertrophic pyloric stenosis is by far the most common cause of gastric outlet obstruction (GOO) in young infants, with more than 90% of cases presenting between 3 and 10 weeks after birth. While cases of late onset pyloric stenosis beyond infancy have been reported, the etiology is poorly understood. We report our experience of 5 cases, describing the similarities and differences in management of our patient population which happens to be the second largest reported in literature.
Methods:
From July 2014 to June 2018 (4 years) a total of five patients of primary acquired GOO were encountered at our center.
Results:
The age range was 3 to 6 years and only one of them was a female. All presented with characteristic nonbilious vomiting that was recurrent and episodic. Upper GI (gastrointestinal) contrast study series revealed a dilated stomach and delayed gastric emptying. Upper GI endoscopy also demonstrated a dilated stomach without any intraluminal polyp, ulcer or any other pathology. Intraoperatively the pylorus had no evidence of scarring, inflammation, external compression or any mass in and around the pylorus. A retrocolic gastrojejunostomy was curative in all patients.
Conclusion:
Though rare, one must maintain a high index of suspicion for primary acquired GOO in the differential diagnosis of older children with nonbilious vomiting and failure to thrive. Following appropriate diagnostic workup, surgical interventions should be performed expeditiously because adequate nutrition is key to proper physical and mental development of the child. Further research will hopefully elucidate the underlying pathophysiology in order to guide clinical options for both prevention and treatment.
Type Of Study:
Retrospective single center study.
Level Of Evidence:
Level 4.
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